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ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Organism: Rhesus monkey (Simian)

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[#E90547Si] ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Organism: Rhesus monkey (Simian)

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E90547Si | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Organism: Rhesus monkey (Simian), 96T
More informations about ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Organism: Rhesus monkey (Simian) in Antibody-antibodies.com

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(1) Modulation the crosstalk between tumor-associated macrophages and non-small cell lung cancer to inhibit tumor migration and invasion by ginsenoside Rh2.[TOP]

Pubmed ID :29783929
Publication Date : //
Tumor-associated macrophages (TAMs) play a critical role in modulating the tumor microenvironment and promote tumor metastases. Our studies have demonstrated that ginsenoside Rh2 (G-Rh2), a monomeric compound extracted from ginseng, is a promising anti-tumor agent in lung cancer cells. However, it remains unclear whetherG-Rh2 can modulate the differentiation of TAMs and its interaction with tumor microenvironment. In this study, we investigated how G-Rh2 regulates the phenotype of macrophages and affects the migration of non-small cell lung cancer (NSCLC) cells.

Authors : Li Honglin, Huang Nan, Zhu Weikang, Wu Jianchun, Yang Xiaohui, Teng Wenjing, Tian Jianhui, Fang Zhihong, Luo Yingbin, Chen Min, Li Yan,



(2) Puerarin prevents vascular endothelial injury through suppression of NF-κB activation in LPS-challenged human umbilical vein endothelial cells.[TOP]

Pubmed ID :29775893
Publication Date : //
In the present study, we aimed to explore the effects of puerarin on vascular endothelial cell injury induced by lipopolysaccharide (LPS) and its underlying mechanisms.

Authors : Deng Hua-Fei, Wang Sha, Li Lian, Zhou Qin, Guo Wan-Bei, Wang Xiao-Li, Liu Mei-Dong, Liu Ke, Xiao Xian-Zhong,



(3) The Status of Nitric Oxide and its Backup, Heme Oxygenase 1, in Thromboangiitis Obliterans.[TOP]

Pubmed ID :29766003
Publication Date : //
Until recently, a gene polymorphism in the promoter region of endothelial nitric oxide synthase has been suggested as a risk factor for thromboangiitis obliterans (TAO) development. The aim of this study was to compare the metabolites of nitric oxide (NO) and its backup, heme-oxygenase-1 (HMOX1), between TAO patients and those of a smoking control group matched by race, age, sex, and smoking habits.

Authors : Aliee Ali, Zahedi Avval Farnaz, Taheri Hossein, Moghadam Saeedeh Mehraban, Soukhtanloo Mohammad, Hamidi Alamdari Daryoush, Fazeli Bahare,



(4) Maternal Serum Endocan Concentration in Pregnancies Complicated by Intrauterine Growth Restriction.[TOP]

Pubmed ID :29742984
Publication Date : //
Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis. Therefore, this study aimed to investigate the relationship between maternal endocan serum level and intrauterine growth restriction (IUGR) as well as ultrasound Doppler flow measurements indicating placental insufficiency.

Authors : Szpera-Gozdziewicz Agata, Kosicka Katarzyna, Gozdziewicz Tomasz, Krzyscin Mariola, Wirstlein Przemyslaw, Siemiatkowska Anna, Glowka Franciszek, Wender-Ozegowska Ewa, Breborowicz Grzegorz H,



(5) Detection of early-stage extrahepatic cholangiocarcinoma in patients with biliary strictures by soluble B7-H4 in the bile.[TOP]

Pubmed ID :29736314
Publication Date : //
Increasing evidence has demonstrated that serum soluble B7-H4 (sB7-H4) is a useful tumour marker for cancer diagnosis and prognosis evaluation. Whether sB7-H4 is expressed in the bile of cholangiocarcinoma (CC) and is related to the progression of CC need to be explored. Bile sB7-H4 was obtained through endoscopic retrograde cholangiopancreatography (ERCP) from 213 patients with biliary strictures and detected was detected by a B7-H4 ELISA kit. Diagnostic value was compared among bile sB7-H4, CA19-9, CA12-5, CEA and ERCP-based cytological/tissue examination. Additionally, the correlations between the bile sB7-H4 concentration and the clinical characteristics of early-stage cholangiocarcinoma (ESCC) were studied. The bile sB7-H4 levels of patients with ESCC were significantly higher than in patients with benign biliary strictures (BBS) (<0.001). The receiver operating characteristic (ROC) curves of CA19-9, CA12-5 and CEA were 0.713, 0.554 and 0.451, respectively, were significantly lower than the ROC curves of bile sB7-H4 (0.837), the sensitivity of ERCP-based cytological/tissue examination was 57.5% and 68.4%, which was lower than that of bile sB7-H4 (81.7%) at cut-off value. A high level of bile sB7-H4 in patients with ESCC was found to be correlated with vascular invasion (<0.001), lymph node metastasis (<0.001) and TNM stage (=0.018), respectively. The overall survival rate (OS) of ESCC patients in the high sB7-H4 group was significantly lower than the OS of patients in the low sB7-H4 group (=0.009). Bile sB7-H4 could serve as a valuable biomarker for patients with ESCC and high levels of bile sB7-H4 correlate with poor clinical outcomes.

Authors : Ke Wenbo, Zeng Li, Hu Yunbi, Chen Sisi, Tian Min, Hu Qinggang,



(6) Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway.[TOP]

Pubmed ID :29725404
Publication Date : //
The effects of hydrogen sulfide (HS) on cancer are controversial. Our group previously demonstrated that exogenous HS promotes the development of cancer via amplifying the activation of the nuclear factor-κB signaling pathway in hepatocellular carcinoma (HCC) cells (PLC/PRF/5). The present study aimed to further investigate the hypothesis that exogenous HS promotes PLC/PRF/5 cell proliferation and migration, and inhibits apoptosis by activating the signal transducer and activator of transcription 3 (STAT3)-cyclooxygenase-2 (COX-2) signaling pathway. PLC/PRF/5 cells were treated with 500 µmol/l NaHS (a donor of HS) for 24 h. The expression levels of phosphorylated (p)-STAT3, STAT3, cleaved caspase-3 and COX-2 were measured by western blot assay. Cell viability was detected by Cell Counting kit-8 assay. Apoptotic cells were observed by Hoechst 33258 staining. The expression of STAT3 and COX-2 messenger RNA (mRNA) was detected by semiquantitative reverse transcription-polymerase chain reaction. The production of vascular endothelial growth factor (VEGF) was evaluated by ELISA. The results indicated that treatment of PLC/PRF/5 cells with 500 µmol/l NaHS for 24 h markedly increased the expression levels of p-STAT3 and STAT3 mRNA, leading to COX-2 and COX-2 mRNA overexpression, VEGF induction, decreased cleaved caspase-3 production, increased cell viability and migration, and decreased number of apoptotic cells. However, co-treatment of PLC/PRF/5 cells with 500 µmol/l NaHS and 30 µmol/l AG490 (an inhibitor of STAT3) or 20 µmol/l NS-398 (an inhibitor of COX-2) for 24 h significantly reverted the effects induced by NaHS. Furthermore, co-treatment of PLC/PRF/5 cells with 500 µmol/l NaHS and 30 µmol/l AG490 markedly decreased the NaHS-induced increase in the expression level of COX-2. By contrast, co-treatment of PLC/PRF/5 cells with 500 µmol/l NaHS and 20 µmol/l NS-398 inhibited the NaHS-induced increase in the expression level of p-STAT3. In conclusion, the findings of the present study provide evidence that the STAT3-COX-2 signaling pathway is involved in NaHS-induced cell proliferation, migration, angiogenesis and anti-apoptosis in PLC/PRF/5 cells, and suggest that the positive feedback between STAT3 and COX-2 may serve a crucial role in hepatocellular carcinoma carcinogenesis.

Authors : Zhen Yulan, Wu Qiaomei, Ding Yiqian, Zhang Wei, Zhai Yuansheng, Lin Xiaoxiong, Weng Yunxia, Guo Ruixian, Zhang Ying, Feng Jianqiang, Lei Yiyan, Chen Jingfu,



(7) Vitreous Levels of Luteinizing Hormone and VEGF are Strongly Correlated in Healthy Mammalian Eyes.[TOP]

Pubmed ID :29677452
Publication Date : //
Purpose/Aim: Luteinizing hormone (LH) is known to function as a key regulator of vascular endothelial growth factor (VEGF) expression in reproductive organs. In recent years, LH has also been detected in human vitreous and LH receptors have been identified in human retina. This study was aimed to investigate a potential correlation between LH and VEGF levels in healthy mammalian eyes to provide supporting evidence of LH's potential involvement in intraocular VEGF regulation.

Authors : Movsas Tammy Z, Sigler Robert, Muthusamy Arivalagan,



(8) [Vaspin protects against lipopolysaccharide-induced acute respiratory distress syndrome in mice by inhibiting inflammation and protecting vascular endothelium via PI3K/Akt signal pathway].[TOP]

Pubmed ID :29643033
Publication Date : //
To investigate the effects of Vaspin on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) in mice and explore the possible mechanism.

Authors : Li Wen, Qi Di, Chen Lan, Zhao Yan, Deng Wang, Tang Xu-Mao, Wang Dao-Xin,



(9) Effect of diallyl trisulfide on ischemic tissue injury and revascularization in a diabetic mouse model.[TOP]

Pubmed ID :29642134
Publication Date : //
Allitridin (diallyl trisulfide, DATS) is an extract from garlic (Allium sativum) that putatively improves endothelial function and is protective against cardiovascular diseases. Endothelial dysfunction after tissue ischemia in diabetic patients is partially due to poor angiogenic response. This study investigated whether DATS may improve angiogenesis in a diabetic mouse model with hind limb ischemia.

Authors : Yang Hai-Bing, Liu Hui-Min, Yan Jin-Chuan, Lu Zhao-Yang,



(10) Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients.[TOP]

Pubmed ID :29622969
Publication Date : //
Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis.

Authors : El Baz Tarek Z, Khamis Osama A, El-Shehaby Amal, Chahine Hussein, Alaa Al-Din Ahmed Ahmad, Alsawasany Mostafa A,