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ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Organism: Rhesus monkey (Simian)

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[#E90547Si] ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Organism: Rhesus monkey (Simian)

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E90547Si | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Organism: Rhesus monkey (Simian), 96T
More informations about ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Organism: Rhesus monkey (Simian) in Antibody-antibodies.com

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(1) Complement Factor C3 Methylation and mRNA Expression Is Associated to BMI and Insulin Resistance in Obesity.[TOP]

Pubmed ID :30104553
Publication Date : //
Epigenetic marks, and especially DNA methylation, are becoming an important factor in obesity, which could help to explain its etiology and associated comorbidities. Adipose tissue, now considered as an important endocrine organ, produces complement system factors. Complement component 3 () turns out to be an important protein in metabolic disorders, via either inflammation or the subproduct acylation stimulating protein (ASP) which directly stimulates lipid storage. In this study, we analyze DNA methylation in adipose tissue from subjects with a different grade of obesity. Adipose tissue samples were collected from subjects with a different degree of obesity determined by their body mass index (BMI) as: Overweight subjects (BMI ≥ 25 and <30), obese class 1/2 subjects (BMI ≥ 30 and <40) and obese class 3 subjects (BMI ≥ 40). C3 DNA methylation was measured for 7 CpGs by pyrosequencition using the Pyromark technology (Qiagen, Madrid Spain). C3 messenger RNA (mRNA) levels were analyzed by pre-designed Taqman assays (Applied biosystems, Foster City, CA, USA) and ASP/C3a was measured using a ELISA kit. The data were analyzed using the statistic package SPSS. DNA methylation levels were lower in the morbid obese group. Accordingly, methylation correlated negatively with BMI and leptin. However, mRNA levels were more associated with insulin resistance, and positive correlations with insulin, glucose and homeostasis model assessment-estimated insulin resistance (HOMA-IR) existed. ASP correlated negatively with high density lipoprotein (HDL) cholesterol. methylation levels were associated to adiposity variables, such as BMI and leptin, while the mRNA levels were associated to glucose metabolism.

Authors : Castellano-Castillo Daniel, Moreno-Indias Isabel, Fernandez-Garcia Jose Carlos, Clemente-Postigo Mercedes, Castro-Cabezas Manuel, Tinahones Francisco José, Queipo-Ortuño María Isabel, Cardona Fernando,



(2) Zedoarondiol Attenuates Endothelial Cells Injury Induced by Oxidized Low-Density Lipoprotein via Nrf2 Activation.[TOP]

Pubmed ID :30064139
Publication Date : //
Zedoarondiol, a sesquiterpene lactone compound, showed an anti-proliferative activity on vascular smooth muscle cells in our previous study. However, whether it has a beneficial effect on endothelial cells injury induced by oxidized low-density lipoprotein (ox-LDL) remains unclear. This study was designed to investigate the protective effect of zedoarondiol on ox-LDL-induced injury of endothelial cells and explored its underlying mechanism.

Authors : Mao Huimin, Tao Tianqi, Wang Xiaoren, Liu Mi, Song Dandan, Liu Xiuhua, Shi Dazhuo,



(3) Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling.[TOP]

Pubmed ID :29996135
Publication Date : //
We investigated the regulation of endothelin-1 (ET-1) expression in in vivo high-fat diet (HFD)-fed mice and in vitro cultured human aortic endothelial cells (HAECs).

Authors : Zhang Juan, Zhao Wen-Shu, Wang Xin, Xu Lin, Yang Xin-Chun,



(4) Thymosin β4 promotes endothelial progenitor cell angiogenesis via a vascular endothelial growth factor‑dependent mechanism.[TOP]

Pubmed ID :29956769
Publication Date : //
Endothelial progenitor cells (EPCs) are a promising cell source for tissue repair and regeneration, predominantly through angiogenesis promotion. Paracrine functions serve a pivotal role in EPC‑mediated angiogenesis, which may be impaired by various cardiovascular risk factors. Therefore, it is important to identify a solution that optimizes the paracrine function of EPCs. Thymosin β4 (Tβ4) is a peptide with the potential to promote tissue regeneration and wound healing. A previous study demonstrated that Tβ4 enhances the EPC‑mediated angiogenesis of the ischemic myocardium. In the present study, whether Tβ4 improved angiogenesis by enhancing the paracrine effects of EPCs was investigated. A tube formation assay was used to assess the effect of angiogenesis, and the paracrine effects were measured using an ELISA kit. The results indicated that Tβ4 improved the paracrine effects of EPCs, evidenced by an increase in the expression of vascular endothelial growth factor (VEGF). EPC‑conditioned medium (EPC‑CM) significantly promoted human umbilical vein endothelial cell angiogenesis in vitro, which was further enhanced by pretreatment with Tβ4. The effect of Tβ4 pretreated EPC‑CM on angiogenesis was abolished by VEGF neutralizing antibody in vitro, indicating that increased VEGF secretion had a pivotal role in Tβ4‑mediated EPC angiogenesis. Furthermore, transplantation of EPCs pretreated with Tβ4 into infarcted rat hearts resulted in significantly higher VEGF expression in the border zone, compared with EPC transplantation alone. To further investigate whether the Akt/eNOS pathway was involved in Tβ4‑induced VEGF secretion in EPCs, the expression levels of VEGF in EPC‑CM were significantly decreased following knockdown of Akt or eNOS by small interfering RNA transfection. In conclusion, Tβ4 significantly increased angiogenesis by enhancing the paracrine effects of EPCs, evidenced by the increased expression of VEGF. The RAC‑α serine/threonine‑protein kinase/endothelial nitric oxide synthase signal transduction pathway was involved in the regulation of Tβ4‑induced VEGF secretion in EPCs. Further studies are required to investigate the long‑term prognosis of patients with coronary heart disease following Tβ4‑pretreated EPC transplantation.

Authors : Zhao Yanbo, Song Jiale, Bi Xukun, Gao Jing, Shen Zhida, Zhu Junhui, Fu Guosheng,



(5) Effects of TNF-α in rheumatoid arthritis via attenuating α1 (I) collagen promoter.[TOP]

Pubmed ID :29949166
Publication Date : //
To explore the role of TNF-α in the peripheral blood of patients with rheumatoid arthritis (RA) and its underlying mechanism.

Authors : Tao L, Xue J-F,



(6) Gadd45a knockdown alleviates oxidative stress through suppressing the p38 MAPK signaling pathway in the pathogenesis of preeclampsia.[TOP]

Pubmed ID :29908638
Publication Date : //
Preeclampsia (PE) is a hypertensive disease associated with vascular oxidative stress (OS). Besides, cell response to OS triggers growth arrest and DNA damage inducible alpha (Gadd45a). Herein, we investigated the effect of Gadd45a on OS in PE.

Authors : Li Fa-Hong, Han Na, Wang Yong, Xu Qian,



(7) The CD40/CD40L system regulates rat cerebral microvasculature after focal ischemia/reperfusion via the mTOR/S6K signaling pathway.[TOP]

Pubmed ID :29843579
Publication Date : //
The role of CD40/CD40 ligand (CD40L) in microvascular thrombosis is now widely accepted. However, the exact mechanisms linking the CD40/CD40L system and the soluble form of CD40L (sCD40L) with microvascular thrombosis are currently a topic of intensive research. The objective of this study was to assess the potential mechanisms in CD40/CD40L system-regulated microvascular thrombosis after focal ischemia/reperfusion (I/R).

Authors : Jiang Run-Hao, Xu Xiao-Quan, Wu Chen-Jiang, Lu Shan-Shan, Zu Qing-Quan, Zhao Lin-Bo, Liu Sheng, Shi Hai-Bin,



(8) [Effect of vascular endothelial growth factor 165-loaded porous poly (ε-caprolactone) scaffolds on the osteogenic differentiation of adipose-derived stem cells].[TOP]

Pubmed ID :29806274
Publication Date : //
To explore the effect of vascular endothelial growth factor 165 (VEGF )-loaded porous poly (ε-caprolactone) (PCL) scaffolds on the osteogenic differentiation of adipose-derived stem cells (ADSCs).

Authors : Xu Wanlin, Lu Hao, Ye Jinhai, Yang Wenjun,



(9) Modulation the crosstalk between tumor-associated macrophages and non-small cell lung cancer to inhibit tumor migration and invasion by ginsenoside Rh2.[TOP]

Pubmed ID :29783929
Publication Date : //
Tumor-associated macrophages (TAMs) play a critical role in modulating the tumor microenvironment and promote tumor metastases. Our studies have demonstrated that ginsenoside Rh2 (G-Rh2), a monomeric compound extracted from ginseng, is a promising anti-tumor agent in lung cancer cells. However, it remains unclear whetherG-Rh2 can modulate the differentiation of TAMs and its interaction with tumor microenvironment. In this study, we investigated how G-Rh2 regulates the phenotype of macrophages and affects the migration of non-small cell lung cancer (NSCLC) cells.

Authors : Li Honglin, Huang Nan, Zhu Weikang, Wu Jianchun, Yang Xiaohui, Teng Wenjing, Tian Jianhui, Fang Zhihong, Luo Yingbin, Chen Min, Li Yan,



(10) Puerarin prevents vascular endothelial injury through suppression of NF-κB activation in LPS-challenged human umbilical vein endothelial cells.[TOP]

Pubmed ID :29775893
Publication Date : //
In the present study, we aimed to explore the effects of puerarin on vascular endothelial cell injury induced by lipopolysaccharide (LPS) and its underlying mechanisms.

Authors : Deng Hua-Fei, Wang Sha, Li Lian, Zhou Qin, Guo Wan-Bei, Wang Xiao-Li, Liu Mei-Dong, Liu Ke, Xiao Xian-Zhong,