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ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Organism: Rhesus monkey (Simian)

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[#E90229Si] ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Organism: Rhesus monkey (Simian)


E90229Si | ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Organism: Rhesus monkey (Simian), 96T
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(1) New Approach in Acne Therapy: A Specific Bacteriocin Activity and a Targeted Anti IL-8 Property in Just 1 Probiotic Strain, the L. salivarius LS03.[TOP]

Pubmed ID :29782471
Publication Date : //
The aim of this research was to assess the antibacterial activity of Lactobacillus salivarius LS03 (DSM 22776) against Propionibacterium acnes and its anti-inflammatory properties by inhibiting P. acnes-induced interleukin-8 (IL-8) release.

Authors : Deidda Francesca, Amoruso Angela, Nicola Stefania, Graziano Teresa, Pane Marco, Mogna Luca,

(2) Puerarin prevents vascular endothelial injury through suppression of NF-κB activation in LPS-challenged human umbilical vein endothelial cells.[TOP]

Pubmed ID :29775893
Publication Date : //
In the present study, we aimed to explore the effects of puerarin on vascular endothelial cell injury induced by lipopolysaccharide (LPS) and its underlying mechanisms.

Authors : Deng Hua-Fei, Wang Sha, Li Lian, Zhou Qin, Guo Wan-Bei, Wang Xiao-Li, Liu Mei-Dong, Liu Ke, Xiao Xian-Zhong,

(3) Ptprj-as1 mediates inflammatory injury after intracerebral hemorrhage by activating NF-κB pathway.[TOP]

Pubmed ID :29771434
Publication Date : //
We aimed at investigating the expression of long non-coding RNA (lncRNA) Ptprj-as1 and the role of lncRNAPtprj-as1 in inflammatory cells after intracerebral hemorrhage and its potential mechanism.

Authors : Wen J, Yang C-Y, Lu J, Wang X-Y,

(4) Peritoneal dialysis effectively removes toxic substances and improves liver functions of liver failure patients.[TOP]

Pubmed ID :29762845
Publication Date : //
Liver failure (LF) is a clinically complex disorder that characterizes with hepatic dysfunction. This study aimed at observing the therapeutic effects of peritoneal dialysis on liver function in LF patients.

Authors : Zhao W-X, Liu X-M, Yu C-M, Xu H, Dai J-R, Chen H-Y, Li L, Chen F, Ou Y-L, Zhao Z-K,

(5) Free fatty acids mediates human umbilical vein endothelial cells inflammation through toll-like receptor-4.[TOP]

Pubmed ID :29762844
Publication Date : //
To investigate the role of Toll-like receptor-4 (TLR4) in the free fatty acids (FFAs) induced human umbilical vein endothelial cells (HUVECs) inflammation and to explore the underlying mechanisms.

Authors : Chen L, Yu C-X, Song B, Cai W, Liu C, Guan Q-B,

(6) MicroRNA-92a promotes tumor growth and suppresses immune function through activation of MAPK/ERK signaling pathway by inhibiting PTEN in mice bearing U14 cervical cancer.[TOP]

Pubmed ID :29752775
Publication Date : //
Cervical cancer is known as the possible outcome of genital infection, while the molecular mechanisms of initiation, development, and metastasis of cervical cancer have not yet been fully elucidated. Our study aims to investigate the effects of microRNA-92a (miR-92a) on tumor growth and immune function by targeting PTEN via the MAPK/ERK signaling pathway in tumor-bearing mice. C57BL/6 female mice were used for tumor-bearing mouse models and their tumor and adjacent normal tissues were collected, and normal cervical tissues were obtained from normal mice. Serum levels of tumor necrosis factor-α (TNF-α) and soluble interleukin-2 receptor (sIL-2R) were detected by ELISA. The cells were divided into the normal, blank, negative control (NC), miR-92a mimic, miR-92a inhibitor, siRNA-PTEN, and miR-92a inhibitor + siRNA-PTEN groups. Dual-luciferase reporter assay was adopted to determine the relationship between PTEN and miR-92a. Expressions of miR-92a, PTEN, TNF-α, sIL-2R, ERK1, and ERK2 were tested by RT-qPCR and Western blotting. Cell proliferation was detected by cell count kit-8 (CCK-8); cell cycle and apoptosis were detected by flow cytometry. Compared with the normal cervical tissues and adjacent normal tissues, the cervical cancer tissues exhibited increased expressions of miR-92a, p-ERK1/2, and serum levels of TNF-α and sIL-2R while decreased PTEN expression. PTEN was confirmed to be the target gene of miR-92a. As compared with the blank and NC groups, expressions of miR-92a, ERK1 and ERK2 increased, and expressions of PTEN decreased in the miR-92a mimic group. The miR-92a mimic group exhibited increased expression levels of TNF-α and sIL-2R, cell proliferation, and cell number in S phase but decreased cell apoptosis, and cell number in G0/G1 phase, while the miR-92a inhibitor group followed opposite trends. miR-92a promotes tumor growth and suppresses immune function by inhibiting PTEN via activation of the MAPK/ERK signaling pathway in mice bearing U14 cervical cancer.

Authors : Li Zeng-Hui, Li Lei, Kang Lin-Ping, Wang Yan,

(7) Protective effect and mechanism of ginsenoside Rg1 in cerebral ischaemia-reperfusion injury in mice.[TOP]

Pubmed ID :29710487
Publication Date : //
Ginsenoside Rg1 is regarded as one of main bioactive compounds responsible for pharmaceutical actions of ginseng with little toxicity and has been shown to have possibly neuroprotective effects. However, the mechanism of its neuroprotection for acute ischemic stroke is still elusive. The purpose of present study is thus to assess the neuroprotective effects of the ginsenoside Rg1 against neurological injury in a mice model of cerebral ischemia/reperfusion (I/R), and then to explore the mechanisms for these neuroprotective effects.

Authors : Wang Le, Zhao Hong, Zhai Zhen-Zhen, Qu Li-Xin,

(8) The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway.[TOP]

Pubmed ID :29693177
Publication Date : //
Acne rosacea is a type of chronic dermatosis with the characteristics of erubescence, angiotelectasis and pustule formation. However, current treatment methods are limited due to the side effects. Artesunate demonstrated a promising therapeutic efficacy with a high safety margin. HaCaT cells were treated with antibacterial peptide LL‑37 to simulate rosacea caused by Demodex folliculorum (D. folliculorum) infection. Cell Counting kit 8 and flow cytometry assays were performed to measure cellular proliferation, apoptosis, the stage of the cell cycle and reactive oxygen species generation in order to determine the level of cell damage. Then the damaged cells were treated with different concentrations of artesunate and doxycycline to determine the therapeutic effect of artesunate. Pro‑inflammatory cytokines tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑6, IL‑8 and C‑C motif chemokine 2 (MCP‑1) were measured using an ELISA, while western blotting was used to detect the expression of Janus kinase 2 (JAK2) and signal transducer and transcription activator (STAT3). As a result, LL‑37 treated HaCaT cells decreased in cell viability, had an increased apoptotic rate and cell cycle arrest, indicating that cell damage caused by rosacea was simulated. In addition, upregulated concentrations of the pro‑inflammatory cytokines TNF‑α, IL‑6, IL‑8 and MCP‑1 were attenuated in the artesunate group in a dose‑dependent fashion, indicating the therapeutic effect of artesunate. Furthermore, higher concentrations of artesunate exhibited an improved effect compared with the doxycycline group. In addition, increased expression levels of JAK2 and STAT3 following treatment with LL‑37 suggested that rosacea caused by D. folliculorum infection may lead to inflammation through the JAK/STAT signaling pathway. In conclusion, the potential mechanism by which damage occurs in rosacea was revealed and a promising therapeutic method against rosacea was demonstrated.

Authors : Li Ting, Zeng Qingwen, Chen Xingming, Wang Guojiang, Zhang Haiqing, Yu Aihua, Wang Hairui, Hu Yang,

(9) In Vivo Two-Photon Fluorescence Imaging of the Activity of the Inflammatory Biomarker LTAH in a Mouse Pneumonia Model.[TOP]

Pubmed ID :29682967
Publication Date : //
Severe atmospheric haze caused by industrial pollution has severely affected human health and led to the increasing incidence of cardiopulmonary diseases, including pneumonia. Conventional methods for diagnosis of pneumonia are complicated and tedious, and current clinical imaging techniques might cause organ injuries to some extent. Therefore, an accurate, fast, and intact imaging method must be developed to diagnose pneumonia in the early stages. In this study, we propose a new two-photon fluorescence probe, named as ASPC, for detection of the activity of the inflammatory biomarker LTAH through specific recognition and cleavage of amides containing the unnatural amino acid l-AspBzl. The activity of LTAH in the lung tissues of mice was rapidly and accurately monitored for the first time and could be an indicator for diagnosis of pneumonia. The severity of pneumonia in mice caused by haze particulate was determined through imaging the activity of LTAH as biomarker and confirmed using a commercial ELISA kit of interleukin-1β. This work provides a promising method for clinical detection of pneumonia and for screening specific depressors of LTAH as potential drug candidates.

Authors : Wang Hui, Xue Ke, Li Ping, Yang Yuyun, He Zixu, Zhang Wei, Zhang Wen, Tang Bo,

(10) Tanshinone IIA protects murine chondrogenic ATDC5 cells from lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-203a.[TOP]

Pubmed ID :29679904
Publication Date : //
Osteoarthritis is the most common bone-joint disease in middle and older people all over the world. Tanshinone IIA (Tan IIA) is the main lipophilic diterpenoid isolated from the root of Salvia miltiorrhiza Bunge (Lamiaceae). This study analyzed the protective effects of Tan IIA on lipopolysaccharide (LPS)-induced murine chondrogenic ATDC5 cell inflammatory injury model.

Authors : Luan Luan, Liang Zhiyuan,