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ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Organism: Rhesus monkey (Simian)

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[#E90229Si] ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Organism: Rhesus monkey (Simian)

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E90229Si | ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Organism: Rhesus monkey (Simian), 96T
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(1) Chitosan inhibits inflammation and adipogenesis of orbital fibroblasts in Graves ophthalmopathy.[TOP]

Pubmed ID :30090014
Publication Date : //
The aim of this study was to investigate the roles of chitosan in inflammation and adipogenesis of primary cultured orbital fibroblasts in Graves ophthalmopathy (GO).

Authors : Xiong Haibo, Wu Mingxing, Zou Hongmi, Jiang Shaoqiu, Yi Hong, Yi Taisong, Wang Qian, Liu Danning, Zhou Yu, Wei Changzheng, Zhou Xiyuan,



(2) Astragalus membranaceus (Fisch.) Bunge repairs intestinal mucosal injury induced by LPS in mice.[TOP]

Pubmed ID :30075775
Publication Date : //
Astragalus membranaceus (Fisch.) Bunge is one of the most widely used traditional Chinese herbal medicines. It is used as immune stimulant, tonic, antioxidant, hepatoprotectant, diuretic, antidiabetic, anticancer, and expectorant. The purpose of the study was to investigate the curative effects of the decoction obtained from Astragalus membranaceus root in intestinal mucosal injury induced by LPS in mice. An LPS-induced intestinal mucosal injury mice model was applied in the study.

Authors : Cui Yizhe, Wang Qiuju, Sun Rui, Guo Li, Wang Mengzhu, Jia Junfeng, Xu Chuang, Wu Rui,



(3) Tumour necrosis factor-related apoptosis-inducing ligand expression in patients with diabetic nephropathy.[TOP]

Pubmed ID :29999450
Publication Date : //
The objective of this study was to evaluate the expression profile of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in patients with diabetic nephropathy (DN).

Authors : Chang Wei-Wei, Liang Wei, Yao Xin-Ming, Zhang Liu, Zhu Li-Jun, Yan Chen, Jin Yue-Long, Yao Ying-Shui,



(4) [The effects of macrophages with high expression of TL1A on activation and proliferation of hepatic stellate cells in vitro].[TOP]

Pubmed ID :29996202
Publication Date : //
To explore the effects of macrophages with high expression of TL1A on the activation and proliferation of HSCs in vitro. The Bone marrow-derived macrophages (BMMs) and peritoneal macrophages (PMs) from wild type (WT) and myeloid-overexpressed TL1A transgenic mice were isolated, differentiated and activated. HSCs were harvested from activated macrophages culture supernatant (CM). HSCs were detected by immunofluorescence and real-time Q-PCR. And the proliferation was detected by CCK-8 and BrdU assay kit. The levels of IL-1β and PDGF-BB in macrophage culture supernatants were determined by enzyme-linked immunosorbent assay (ELISA). BMMs-derived CM-intervention HSCs were used to detect the expression of α-smooth muscle actin (α-SMA) on the 2nd, 4th and 6th day respectively by immunofluorescence method. There was no significant difference between the two groups on the 2 nd and the 6th day, > 0.05; On day 4, the CM/Tg group was significantly higher than that of CM/WT group, < 0.01; the results of CMs derived from PMs were consistent with the above trend. The expression of α-SMA mRNA on the 2nd, 4th and 6th day was detected by real-time Q-PCR method using BM-derived CMs. No significant difference was found between the groups on the 2nd day ( > 0.05).α-SMA mRNA increased further on the 4th and 6th day, and the level of CM/Tg in CM/Tg group was significantly higher than that in CM/WT group ( < 0.05). The detection results of CMs derived from PMs were consistent with the above trend. The results of CCK-8 assay and BrdU assay showed that the proliferation rate of HSCs in CM Tg group was significantly higher than that in CM/WT group ( < 0.01). The CMs derived from PMs were used to interfere with HSCs. And the results were consistent with the above trend. For BMMs, the levels of IL-1β and PDGF-BB in the lipopolysaccharide (LPS) + IFNγ/Tg culture supernatant were significantly higher than those in the LPS+IFNγ/WT group ( < 0.01). For the culture supernatants of PMs Liquid test results consistent with the above trend. Macrophages with high expression of TL1A could enhance the activation and proliferation of HSCs by increasing the secretion of IL-1β and PDGF-BB.

Authors : Luo Y X, Guo J B, Yin F R, Huo X X, Zheng L B, Zhang H, Zhang X L,



(5) [Effects of flavonoids from Pyrrosiae folium on pathological changes and inflammatory response of diabetic nephropathy].[TOP]

Pubmed ID :29945390
Publication Date : //
Diabetic nephropathy (DN) is closely related to immune-mediated inflammatory damage. Pyrrosiae folium is used commonly for the urinary system diseases with a good efficacy, which contains abundant flavonoids (SWHT). This study was performed to investigate the therapeutic effect of SWHT on DN and its effect on inflammatory response. In this study, the main active components of SWHT were identified by high performance liquid chromatography (HPLC). The results showed that SWHT mainly contained mangiferin and isomucoside. Rat model of diabetic nephropathy (DN) was established by feeding high glucose & high fat diet and injecting streptozocin (STZ). Then the rats were randomly divided into control group, DN model group, positive control group, and SWHT groups (50, 100, 200 mg·kg⁻¹, ig). The levels of AGEs and RAGE in serum were measured by ELISA after 12 weeks of drug administration. The serum creatinine, blood urea nitrogen and total protein levels were detected by using test kit. HE staining and transmission electron microscopy were applied to observe the pathological changes and structure of renal tissue. Western blot and ELISA were used to detect the protein expression and content levels of interleukin 6 (IL-6), tumor necrosis factor (TNF-α) and IL-1β in renal tissue. Results showed that SWHT significantly decreased serum AGEs and RAGE levels in DN rats; decreased serum creatinine, blood urea nitrogen and total urinary protein levels, improved renal pathological damages and reduced basement membrane thickening in DN rats. In addition, SWHT down-regulated the protein expression levels of inflammatory mediators IL-6, TNF-α and IL-1β. The research studies indicated that SWHT component had a potential anti-diabetic nephropathy activity, and its improvement effect on pathological damages may be related to reducing inflammation. This provides the basis for the scientific and rational application of P. folium, and also provides active components for further development of Chinese medicine for diabetic nephropathy.

Authors : Liu Xu-Lin, Liu Wen-Ping, Wang Li-Li, Feng Liang,



(6) Ovary stereological features and serum biochemical factors following induction of polycystic ovary syndrome with testosterone enanthate in mice: An experimental study.[TOP]

Pubmed ID :29942935
Publication Date : //
Polycystic ovary syndrome (PCOS) is an endocrine disorder featured by insulin resistance and hyperandrogenism. Testosterone enanthate can induce PCOS in mice models.

Authors : Kalhori Zahra, Soleimani Mehranjani Malek, Azadbakht Mehri, Shariaatzadeh Mohammad Ali,



(7) N-acetyl cysteine inhibits lipopolysaccharide-mediated induction of interleukin-6 synthesis in MC3T3-E1 cells through the NF-kB signaling pathway.[TOP]

Pubmed ID :29929056
Publication Date : //
Interleukin-6 (IL-6) is a potent stimulator of osteoclastic activity. Lipopolysaccharide (LPS) has been shown to regulate the expression of potent inflammatory factors, including TNF-α and IL-6. Currently, effective therapeutic treatments for bacteria-caused bone destruction are limited. N-acetyl cysteine (NAC) is an antioxidant small molecule that possibly modulates osteoblastic differentiation. However, whether NAC can affect the LPS-mediated reduction of IL-6 synthesis in MC3T3-E1 cells is still unknown.

Authors : Guo Ling, Zhang Hui, Li Wangyang, Zhan Danting, Wang Min,



(8) Effect of dexmedetomidine, midazolam, and propofol on lipopolysaccharide-stimulated dendritic cells.[TOP]

Pubmed ID :29904429
Publication Date : //
Dexmedetomidine, midazolam and propofol are common sedative drugs used in the intensive care unit. Lipopolysaccharides (LPS) are a potent inducer of human dendritic cells (DCs) maturation and survival, which induces cytokine production. The present study aimed to investigate the effect and mechanisms of sedative drugs on LPS-induced cytokine production in DCs. The mouse bone marrow-derived dendritic DC2.4 cell line was used in the present study. The Cell Counting Kit-8 assay was used to measure the viability of cells. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10 mRNA expression levels and contents were measured using reverse transcription-quantitative polymerase chain reaction and ELISA, respectively. The expression levels of proteins associated with nuclear factor-κB (NF-κB) and mitogen activated protein kinase signaling pathways were assessed by western blotting. The three sedatives had different roles on TNF-α, IL-1β, IL-6, and IL-10 mRNA expression levels and content in DCs. Dexmedetomidine promoted inflammatory cytokine production at high clinical concentrations (10, 1 and 0.1 µM), however suppressed them at the lowest clinical concentration (0.001 µM), which was associated with NF-κB and c-Jun N-terminal kinase (JNK)-mitogen-activated protein kinase (MAPK) signaling. Midazolam inhibited inflammatory cytokine production via suppression of the NF-κB and JNK signaling pathways. Propofol partly inhibited inflammatory cytokine production, including IL-1β and IL-6, and the anti-inflammatory effect may result from inhibition of JNK-MAPK, and enhanced NF-κB and extracellular signal-regulated kinase-MAPK signaling at clinical concentrations. The present study helped to elucidate the function of sedatives in LPS-induced cytokine production in DCs, which will facilitate rational implementation of these sedatives in patients undergoing tracheal intubation with sepsis or multiple organ dysfunction syndrome.

Authors : Guo Feng, Ding Ying, Yu Xue, Cai Xiujun,



(9) Effect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and disease.[TOP]

Pubmed ID :29900909
Publication Date : //
Interleukin-34 (IL-34) is a recently identified alternative ligand for colony-stimulating factor-1 receptor plays an important role in osteoclastogenesis. The aim of this study was to evaluate the IL-34 levels in gingival crevicular fluid (GCF) and plasma in subjects with chronic periodontitis and to evaluate the effect of nonsurgical periodontal therapy on the GCF and plasma IL-34 levels.

Authors : Guruprasad C N, Pradeep A R,



(10) Investigation of Immune-Regulatory Effects of Mageumsan Hot Spring via Protein Microarray .[TOP]

Pubmed ID :29853747
Publication Date : //
Empirical evidences for efficacy of hot spring (HS) water in inflammatory skin disorders have not been substantiated with sufficient, immunological "hard evidence". HS water, characterized by its weakly-alkaline properties and low total dissolved solids content, has been known to alleviate various immune-inflammatory skin diseases, including atopic dermatitis (AD).

Authors : Hahn Hyung Jin, Kim Jung Soo, Kim Yeong Ho, Lee Young Bok, Yu Dong Soo, Kim Jin-Wou,