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ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Organism: Rhesus monkey (Simian)

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[#E90050Si] ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Organism: Rhesus monkey (Simian)


E90050Si | ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Organism: Rhesus monkey (Simian), 96T
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(1) Decreased serum levels of CTRP12/adipolin in patients with coronary artery disease in relation to inflammatory cytokines and insulin resistance.[TOP]

Pubmed ID :30337217
Publication Date : //
Coronary artery disease (CAD) is the leading cause of death worldwide. Atherosclerosis as the main underlying mechanism of CAD is associated with inflammation and adipose tissue dysfunction. C1q/TNF-related protein12 (CTRP12) is a newly discovered adipokine which is a paralog of adiponectin. CTRP12 has anti-inflammatory and insulin sensitizing effects. Circulating levels of this adipokine have been reported to be lower in patients with type 2 diabetes and women with polycystic ovarian syndrome. The present study was undertaken for the first time to evaluate serum levels of CTRP12 in CAD patients and its association with anthropometric and biochemical parameters. Serum levels of CTRP12 were measured using ELISA kit in 188 CAD patients (angiography confirmed) and 70 controls. The serum levels of adiponectin, TNF-α and IL-6 were measured using ELISA kits. Serum levels of CTRP12 were found to be lower in CAD patients (585.48 ± 201.67 pg/mL) than in the controls (814.86 ± 247.85 pg/mL; p < 0.001). CTRP12 also showed an independent association with the risk of CAD (OR [CI] = 0.998 [0.996-0.999]; p = 0.019). Moreover, it showed an inverse correlation with HOMA-IR (r = -0.298; p = 0.012) and TNF-α (r = -0.269; p = 0.023) and a positive correlation with adiponectin (r = 0.344; p = 0.003) in the controls. In CAD patients, CTRP12 was inversely correlated with BMI (r = -0.181, p = 0.013), HOMA-IR (r = -0.199; p = 0.006), TNF-α (r = -0.259; p < 0.001) and IL-6 (r = -320; p < 0.001) and a positive correlation with high density lipoprotein-cholesterol(r = 0.342; p < 0.001) and adiponectin (r = 0.398; p < 0.001). The present study showed for the first time that serum levels of CTRP12 are independently associated with CAD and that CTRP12 is associated with several CAD risk factors. The results suggest a possible link between CTRP12 and pathogenic mechanisms of atherosclerosis, such as inflammation and high density lipoprotein-cholesterol metabolism; however, more study is required in this regard.

Authors : Fadaei Reza, Moradi Nariman, Kazemi Tooba, Chamani Elham, Azdaki Nahid, Moezibady Sayed Ali, Shahmohamadnejad Shiva, Fallah Soudabeh,

(2) A Putative Association of Interleukin-1β Promoter Polymorphisms and IL-1β Levels in Saudi Diabetic Patients.[TOP]

Pubmed ID :30311584
Publication Date : //
Type 2 diabetes mellitus (T2DM) is a well-known endocrine disorder affecting a significant number of individuals across the globe. Risk factors such as inflammation, obesity, high blood glucose level, cardiovascular disease, and genetic alteration are believed to be the reason for T2DM onset. The current study was intended to envisage the possible association between polymorphisms in the interleukin-1β (IL-1β) promoter and IL-1β serum levels in Saudi T2DM patients. Biochemical parameters such as fasting blood glucose (FBS), percentage glycosylated hemoglobin (HbAic), and lipid profile were measured spectrophotometrically. Serum insulin levels were measured using an immunochemistry analyzer. The commercial enzyme-linked immune assay (ELISA) kit was used to estimate the level of IL-1β in the serum samples. The Sanger sequencing method was adopted to determine single-nucleotide polymorphisms (SNPs) in the IL-1β promoter. We observed a significant (P < 0.001) elevation in FBS, Hb1Ac, insulin, and low-density lipoprotein cholesterol in T2DM patients compared with control individuals. Similarly, IL-1β level were found to be increased by 221% in T2DM patients compared with controls. A nonsignificant genotypic association was observed in the IL-1β gene at the -511C/T and -31C/T positions in T2DM patients compared with control individuals. However, a significant association (P < 0.05) was observed at the allelic level. Further studies on larger sample sizes are recommended to establish the exact role of IL-1β polymorphism in the pathogenesis of T2DM and its genetic risk.

Authors : Tabrez Shams, Ashraf Ghulam Md, Hindawi Salwa,

(3) Complement Factor C3 Methylation and mRNA Expression Is Associated to BMI and Insulin Resistance in Obesity.[TOP]

Pubmed ID :30104553
Publication Date : //
Epigenetic marks, and especially DNA methylation, are becoming an important factor in obesity, which could help to explain its etiology and associated comorbidities. Adipose tissue, now considered as an important endocrine organ, produces complement system factors. Complement component 3 () turns out to be an important protein in metabolic disorders, via either inflammation or the subproduct acylation stimulating protein (ASP) which directly stimulates lipid storage. In this study, we analyze DNA methylation in adipose tissue from subjects with a different grade of obesity. Adipose tissue samples were collected from subjects with a different degree of obesity determined by their body mass index (BMI) as: Overweight subjects (BMI ≥ 25 and <30), obese class 1/2 subjects (BMI ≥ 30 and <40) and obese class 3 subjects (BMI ≥ 40). C3 DNA methylation was measured for 7 CpGs by pyrosequencition using the Pyromark technology (Qiagen, Madrid Spain). C3 messenger RNA (mRNA) levels were analyzed by pre-designed Taqman assays (Applied biosystems, Foster City, CA, USA) and ASP/C3a was measured using a ELISA kit. The data were analyzed using the statistic package SPSS. DNA methylation levels were lower in the morbid obese group. Accordingly, methylation correlated negatively with BMI and leptin. However, mRNA levels were more associated with insulin resistance, and positive correlations with insulin, glucose and homeostasis model assessment-estimated insulin resistance (HOMA-IR) existed. ASP correlated negatively with high density lipoprotein (HDL) cholesterol. methylation levels were associated to adiposity variables, such as BMI and leptin, while the mRNA levels were associated to glucose metabolism.

Authors : Castellano-Castillo Daniel, Moreno-Indias Isabel, Fernandez-Garcia Jose Carlos, Clemente-Postigo Mercedes, Castro-Cabezas Manuel, Tinahones Francisco José, Queipo-Ortuño María Isabel, Cardona Fernando,

(4) [Purple sweet potato anthocyanins attenuates steatohepatitis induced by high fat diet combined with carbon tetrachloride in rats].[TOP]

Pubmed ID :30081974
Publication Date : //
To explore the mechanism of purple sweet potato anthocyanins through NF-κB pathway in attenuating steatohepatitis induced by high fat diet combined with carbon tetrachloride in rats.

Authors : Mi Wei, Han Fulei, Liang Jie, Liang Yanan, Guan Baichu, Xu Hao,

(5) Downregulation of HOTTIP regulates insulin secretion and cell cycle in islet β cells via inhibiting MEK/ERK pathway.[TOP]

Pubmed ID :30070332
Publication Date : //
To investigate the effect of long non-coding RNA (lncRNA) HOTTIP on islet β cells and its underlying mechanism.

Authors : Xu X, Tian J, Li Q-Y,

(6) Effect of Dandelion Extracts on the Proliferation of Ovarian Granulosa Cells and Expression of Hormone Receptors.[TOP]

Pubmed ID :29998889
Publication Date : //
In the current society, infertility related to age has become a social problem. The in vitro fertilization (IVF) success rate in women with poor ovarian response (POR) is very low. Dandelion extract T-1 (DE-T1) is an effective component of the extract from the leaves and stems of Taraxacum officinale, which is one of the medicines used in some patients with POR, but its molecular mechanism remains unclear.

Authors : Wang Tong, Xue Bing, Shao Hui, Wang Shu-Yu, Bai Li, Yin Cheng-Hong, Zhao Huan-Ying, Qi Yong-Chao, Cui Le-Le, He Xin, Ma Yan-Min,

(7) Umbelliferone alleviates hepatic injury in diabetic db/db mice via inhibiting inflammatory response and activating Nrf2-mediated antioxidant.[TOP]

Pubmed ID :29967293
Publication Date : //
The current study was designed to investigate the protective effect and possible mechanisms of umbelliferone (Umb) on liver injury in diabetic C57BL/KsJ-db/db (dbdb) mice. Mice were divided into five groups: wild-type mice group (WY), dbdb mice group, dbdb mice + Metformin (100 mg/kg) group, dbdb mice + Umb (20, 40 mg/kg) group. Blood glucose regulation was assessed by an oral glucose tolerance test (OGTT). At 28 days after drug administration, blood samples were obtained for the analysis of lipids and enzymes related to hepatic function, including alanine aminotransferase (ALT), aspartate aminotransaminase (AST) and total cholesterol (TC) and triglyceride (TG). Expression levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6) and oxidative stress indicators (SOD and MDA) were measured with ELISA kit. The expressions of high-mobility group box 1 (HMGB1), Toll-like receptor (TLR) 4 (TLR4), Myd88, NF-κB, IκB, Nrf2, and HO-1 proteins were also evaluated by Western blotting analysis. The results showed that Umb significantly restored the blood glucose in OGTT, and inhibited the levels of insulin, TG, TC, as well as activities of ALT and AST. Moreover, Umb inhibited diabetic inflammation through down-regulating the expression of HMGB1, TLR4, NF-κB, and IκB. In addition, Umb alleviated oxidative damage in the liver by activating Nrf2-mediated signal pathway. These findings demonstrated that Umb exhibited protective effect against diabetic live injury, which may be through inhibiting HMGB1-induced inflammatory response and activating Nrf2-mediated antioxidant.

Authors : Yin Jiangning, Wang Hanqing, Lu Guoyuan,

(8) Probiotics improve insulin resistance status in an experimental model of Alzheimer's disease.[TOP]

Pubmed ID :29951404
Publication Date : //
Nowadays, Alzheimer's disease (AD) is considered as Type 3 diabetes in which insulin resistance is the common cause of both diseases. Disruption of insulin signaling cascade and insulin resistance can induce AD; and central insulin resistance causes systemic alterations in serum insulin, FBS levels, and lipid profile. Studies have shown that probiotics ( and species) can be used as a nutritional approach to improve these metabolic changes. We assessed the probiotic effect (4 species of and ) on insulin resistance biomarkers in an experimental model of AD. A total of 60 rats were divided into 5 groups: (1) a control group without surgical and dietary intervention; (2) a controlprobiotics group receiving probiotics for 8 weeks, but not receiving any surgical intervention; (3) a group receiving a sham operation in which PBS was injected intrahippocampus but without dietary intervention; (4) an Alzheimer group for which Amyloid-ß (Aß) 1- 42 was injected intrahippocampus but without dietary intervention; (5) and an Alzheimer-probiotics group for which Aß1-42 was injected intrahippocampus and given 2g probiotics for 8 weeks. The FBS levels and lipid profile were measured by a calorimetric method, insulin levels were detected by an ELISA kit, and HOMA-IR was calculated using a formula. ANOVA (one way analysis of variance followed by Bonferroni comparisons post hoc) was used to compare all the variables between groups. Serum glucose, insulin levels, and HOMA-IR index increased in the Alzheimer group compared to the control (p<0.001), while probiotics decreased only insulin level and HOMA-IR index in AP group compared to Alzheimer group (p<0.001). Also, TG levels increased in the Alzheimer group (p<0.001), but no significant difference was detected between Alzheimer and Alzheimerprobiotics group. It seems that probiotics play an effective role in controlling glycemic status of Alzheimer's disease.

Authors : Athari Nik Azm Somayeh, Djazayeri Abolghassem, Safa Majid, Azami Kian, Djalali Mahmoud, Sharifzadeh Mohammad, Vafa Mohammadreza,

(9) Ovary stereological features and serum biochemical factors following induction of polycystic ovary syndrome with testosterone enanthate in mice: An experimental study.[TOP]

Pubmed ID :29942935
Publication Date : //
Polycystic ovary syndrome (PCOS) is an endocrine disorder featured by insulin resistance and hyperandrogenism. Testosterone enanthate can induce PCOS in mice models.

Authors : Kalhori Zahra, Soleimani Mehranjani Malek, Azadbakht Mehri, Shariaatzadeh Mohammad Ali,

(10) [Effects of iodine excess on islet β cells(β-TC-6) function and the mechanism].[TOP]

Pubmed ID :29903184
Publication Date : //
To explore the influences of iodine excess on insulin secret function of mouse insulinoma cells β-TC-6 and the mechanism.

Authors : Sun Zuolong, Wang Xiao, Chen Jin, Duan Peng, Wang Jing, Liu Ying, Guo Huailan,