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ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Organism: Rhesus monkey (Simian)

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[#E90050Si] ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Organism: Rhesus monkey (Simian)


E90050Si | ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Organism: Rhesus monkey (Simian), 96T
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(1) Magnetic multiwalled carbon nanotubes as nanocarrier tags for sensitive determination of fetuin in saliva.[TOP]

Pubmed ID :29734035
Publication Date : //
This paper reports the development and performance of an electrochemical immunosensor using magnetic multiwalled carbon nanotubes (m-MWCNTs) as nanocarrier tags for the determination of human fetuin A (HFA), a relevant biomarker of obesity, insulin resistance, and type-2 diabetes as well as for pancreatic and liver cancers and inflammatory processes. Screen-printed carbon electrodes were grafted with p-aminobezoic acid and streptavidin was covalently immobilized on the electrode surface. A biotinylated capture antibody was immobilized through streptavidin-biotin interaction and a sandwich assay configuration was implemented using m-MWCNTs conjugated with HRP and anti-HFA antibodies as the detection label. The determination of HFA was accomplished by measuring the current produced by the electrochemical reduction of benzoquinone at -200 mV upon addition of HO as HRP substrate. The prepared m-MWCNTs were characterized by SEM, TEM, XRD and EDS. All the steps involved in the immunosensor preparation were monitored by electrochemical impedance spectroscopy and cyclic voltammetry. A linear calibration plot for HFA was found between 20 and 2000 pg/mL with a LOD value of 16 pg/mL. This performance is notably better than that reported for an ELISA kit and a chronoimpedimetric immunosensor. The favorable contribution of m-MWCNTs in comparison with MWCNTs without incorporated magnetic particles to this excellent analytical performance is also highlighted. The immunosensor selectivity against other proteins and potentially interfering compounds was excellent. In addition, the usefulness of the immunosensor was demonstrated by the analysis of HFA in saliva with minimal sample treatment.

Authors : Sánchez-Tirado Esther, González-Cortés Araceli, Yáñez-Sedeño Paloma, Pingarrón José M,

(2) Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits.[TOP]

Pubmed ID :29709922
Publication Date : //
Selenoprotein P (SeP) is a selenium (Se)-rich extracellular protein. SeP is identified as a hepatokine, causing insulin resistance in type 2 diabetes. Thus, the measurement of SeP in serum has received much attention, and several enzyme-linked immunosorbent assay (ELISA) kits for SeP determination are now commercially available. In the present study, we determined the serum SeP levels by our original ELISA and sol particle homogeneous immunoassay (SPIA) methods and also by commercially available kits, and these determinants were compared. We found a kit-dependent correlation of the determinants with our methods. These results suggest that the selection of kit is critical for comparison with our previous reports and for discussing the relationship between the serum SeP levels and disease condition.

Authors : Saito Yoshiro, Misu Hirofumi, Takayama Hiroaki, Takashima Shin-Ichiro, Usui Soichiro, Takamura Masayuki, Kaneko Shuichi, Takamura Toshinari, Noguchi Noriko,

(3) Effect of diallyl trisulfide on ischemic tissue injury and revascularization in a diabetic mouse model.[TOP]

Pubmed ID :29642134
Publication Date : //
Allitridin (diallyl trisulfide, DATS) is an extract from garlic (Allium sativum) that putatively improves endothelial function and is protective against cardiovascular diseases. Endothelial dysfunction after tissue ischemia in diabetic patients is partially due to poor angiogenic response. This study investigated whether DATS may improve angiogenesis in a diabetic mouse model with hind limb ischemia.

Authors : Yang Hai-Bing, Liu Hui-Min, Yan Jin-Chuan, Lu Zhao-Yang,

(4) Circulating bone morphogenetic protein-9 levels are associated with hypertension and insulin resistance in humans.[TOP]

Pubmed ID :29550458
Publication Date : //
It has been demonstrated that bone morphogenetic protein-9 (BMP-9) may have an important role in vascular development and stability. However, the association of circulating BMP-9 with essential hypertension (HTN) has not been established in humans. The objective of this study is to observe the changes of circulating BMP-9 levels in patients with HTN and to investigate the association of circulation BMP-9 and insulin resistance (IR) in a cross-sectional study. Two hundred twenty-five individuals, including 132 patients with hypertension, and 93 healthy controls, were included in the present study. Circulating BMP-9 concentrations were measured with an ELISA kit. The association of circulating BMP-9 with other parameters was analyzed. When compared with healthy subjects, circulating BMP-9 concentrations were markedly lower in HTN patients (46.20 [31.85-62.80] vs. 77.21 [39.33-189.15], P < .01) and correlated negatively with blood pressure and the homeostasis model assessment of insulin resistance (P < .05 or P < .01). Decreasing levels of BMP-9 were independently and markedly related to HTN. In a multiple linear regression analysis, only systolic blood pressure and free fatty acid concentrations were independently associated with circulating BMP-9. Our findings suggest that BMP-9 may be a serum biomarker for HTN and IR.

Authors : Huang Hong, Wang Wei, Yang Gangyi, Zhang Yu, Li Xiaoqiang, Liu Hua, Zhang Lin, Zheng Hongting, Li Ling,

(5) The relationship between IGF-2, IGFBP-2, and IGFBP-3 levels in patients suffering from pre-diabetes.[TOP]

Pubmed ID :29504366
Publication Date : //
Many studies have shown that intervention in the early stages of diabetes may have a pivotal role in reducing the risk of cardiovascular diseases. This study was designed to assess possible relationships between insulin-like growth factor 2 (IGF-2), insulin-like growth factor binding proteins 2 and 3 (IGFBP-2, IGFBP-3) and pre-diabetes. A total of sixty clinically ascertained pre-diabetes cases and twenty-five healthy controls were included. Serum IGF-2 and binding proteins were estimated using commercially available ELISA kit. All groups had a positive correlation between all serum parameters. Multinomial logistic regression showed that all the study parameters directly affected each other. The results could not prove any correlation between IGF-2 and its binding proteins during pre-diabetes stage. Further assessments of these factors in larger groups of males and females in diabetic individuals could be useful to support our hypothesis that these factors change only in diabetes mellitus.

Authors : Ismayilnajadteymurabadi H, Konukoglu D,

(6) Sex differences in insulin and glucagon responses for glucose homeostasis in young healthy Japanese adults.[TOP]

Pubmed ID :29489067
Publication Date : //
It has been reported that glucose responses during the oral glucose tolerance test differ between healthy women and men. However, it remains unknown what factors contribute to these differences between the sexes. The present study analyzed the insulin and glucagon responses during the oral glucose tolerance test in 25 female and 38 male healthy young adults aged 22-30 years. The plasma glucose levels at 120 min were significantly higher in women than men. Insulin secretion was significantly greater at 30, 90 and 120 min from baseline in women than men. Glucagon suppression was greater at 30 and 120 min from baseline in men than women when determined by a sandwich enzyme-linked immunosorbent assay glucagon kit. These results suggest that the differences in glucose responses during the oral glucose tolerance test are mediated by the difference between the sexes in bi-hormonal responses in healthy individuals.

Authors : Horie Ichiro, Abiru Norio, Eto Mami, Sako Ayaka, Akeshima Junya, Nakao Tomoe, Nakashima Yomi, Niri Tetsuro, Ito Ayako, Nozaki Aya, Haraguchi Ai, Akazawa Satoru, Mori Yoshitaka, Ando Takao, Kawakami Atsushi,

(7) High dose of histone deacetylase inhibitors affects insulin secretory mechanism of pancreatic beta cell line.[TOP]

Pubmed ID :29453918
Publication Date : //
Histone deacytylase inhibitors (HDACis) inhibit the deacetylation of the lysine residue of proteins, including histones, and regulate the transcription of a variety of genes. Recently, HDACis have been used clinically as anti-cancer drugs and possible anti-diabetic drugs. Even though HDACis have been proven to protect the cytokine-induced damage of pancreatic beta cells, evidence also shows that high doses of HDACis are cytotoxic. In the present study, we, therefore, investigated the eff ect of HDACis on insulin secretion in a pancreatic beta cell line.

Authors : Yamato Eiji,

(8) Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease.[TOP]

Pubmed ID :29440908
Publication Date : //
Angiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid metabolism and angiogenesis and is elevated in familial hypercholesterolemia, metabolic syndrome, and insulin resistance. This study aims to evaluate the relationship between the fasting serum ANGPTL3 levels and the aortic augmentation index (AIx) in patients with coronary artery disease (CAD).

Authors : Fu Yu-Shan, Wang Ji-Hung, Lee Chung-Jen, Hsu Bang-Gee,

(9) Conditioned medium from contracting skeletal muscle cells reverses insulin resistance and dysfunction of endothelial cells.[TOP]

Pubmed ID :29289515
Publication Date : //
Obese adipose tissue has been characterized with chronic inflammation associated with elevated secretion of inflammatory cytokines and declined secretion of anti-inflammatory cytokines which can impair endothelial function in an endocrine manner. Adipose tissue hypoxia plays a role in the changes of cytokines. Physical exercise/muscle contraction may help preventing cardiovascular disease through improving insulin resistance and endothelium function. However the mechanism is unclear. Skeletal muscle is an endocrine tissue. Contracting muscles secrete myokines which may play roles in the beneficial effect of exercise. In this study, the conditioned medium from electrical pulse stimulation (EPS) regulated skeletal muscle cells was used to explore the mechanism of contraction on endothelial dysfunction and insulin resistance induced by conditioned medium from hypoxic adipocytes.

Authors : Zhao Yihe, Li Nana, Li Zhu, Zhang Da, Chen Liming, Yao Zhi, Niu Wenyan,

(10) Calcium-dependent ultrasound stimulation of secretory events from pancreatic beta cells.[TOP]

Pubmed ID :29214024
Publication Date : //
Our previous studies have indicated that ultrasound can stimulate the release of insulin from pancreatic beta cells, providing a potential novel treatment for type 2 diabetes. The purpose of this study was to explore the temporal dynamics and Ca-dependency of ultrasound-stimulated secretory events from dopamine-loaded pancreatic beta cells in an in vitro setup.

Authors : Suarez Castellanos Ivan, Singh Tania, Balteanu Bogdan, Bhowmick Diti Chatterjee, Jeremic Aleksandar, Zderic Vesna,