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PTH Related Peptide, aa 107_111, Osteostatin, Sheep anti_Human; ELISA

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[#YIA4242.1] PTH Related Peptide, aa 107_111, Osteostatin, Sheep anti_Human; ELISA

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YIA4242.1 | PTH Related Peptide, aa 107_111, Osteostatin, Sheep anti_Human; ELISA, 20 µl.
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(1) New Drugs 2018, part 3.[TOP]

Pubmed ID :30192268
Publication Date : //
This article discusses eight drugs recently approved by the FDA, including their indications and contraindications, precautions, dosage, and nursing considerations. The article also includes summary charts on 14 recently approved antineoplastic drugs and four drugs approved for rare disorders.

Authors : Hussar Daniel A,



(2) Twist on a classic: vitamin D and hypercalcaemia of malignancy.[TOP]

Pubmed ID :29170170
Publication Date : //
Malignancy is the most common cause of hypercalcaemia in the inpatient setting. Most cases are caused by tumour production of parathyroid hormone-related protein and osseous metastases. In less than 1% of cases, hypercalcaemia is driven by increased production of 1,25-dihydroxyvitamin D (1,25(OH)D), a mechanism most commonly seen in haematological malignancies. Here, we describe a woman with metastatic small cell cervical carcinoma who developed hypercalcaemia secondary to paraneoplastic overproduction of 1,25(OH)D, a finding that, to our knowledge, has not been previously associated with this cancer. We also review the current cases of solid tumours reported to have this mechanism of hypercalcaemia and the evidence behind multiple therapeutic approaches.

Authors : Osorio Juan C, Jones Masha G, Schatz-Siemers Nina, Tang Stephanie J,



(3) Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs.[TOP]

Pubmed ID :28941306
Publication Date : //
Low blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations.

Authors : Weidner N, Woods J P, Conlon P, Meckling K A, Atkinson J L, Bayle J, Makowski A J, Horst R L, Verbrugghe A,



(4) Two cases of humoral hypercalcemia of malignancy complicating infantile fibrosarcoma.[TOP]

Pubmed ID :28371408
Publication Date : //
We report two infants with infantile fibrosarcoma (IFS) complicated by severe hypercalcemia. Assessment demonstrated suppressed parathyroid hormone and 1,25-dihydroxyvitamin D levels with elevated circulating levels of parathyroid hormone related protein, indicating the diagnosis of humoral hypercalcemia of malignancy (HHM). HHM is a paraneoplastic syndrome rarely associated with pediatric malignancies. Hypercalcemia manifested clinically with neurologic symptoms and soft tissue calcium deposition and required aggressive management with intravenous fluids, diuretics, and supplemental electrolytes. Following treatment with neoadjuvant chemotherapy, serum calcium levels precipitously declined requiring calcium repletion. These cases highlight the improvement of hypercalcemia secondary to HHM following chemotherapy.

Authors : Hirschfeld Ryan, Welch Jennifer J G, Harrison Douglas J, Kremsdorf Robin, Chawla Anjulika,



(5) Heterotrimeric G proteins in the control of parathyroid hormone actions.[TOP]

Pubmed ID :28363951
Publication Date : //
Parathyroid hormone (PTH) is a key regulator of skeletal physiology and calcium and phosphate homeostasis. It acts on bone and kidney to stimulate bone turnover, increase the circulating levels of 1,25 dihydroxyvitamin D and calcium and inhibit the reabsorption of phosphate from the glomerular filtrate. Dysregulated PTH actions contribute to or are the cause of several endocrine disorders. This calciotropic hormone exerts its actions via binding to the PTH/PTH-related peptide receptor (PTH1R), which couples to multiple heterotrimeric G proteins, including G and G Genetic mutations affecting the activity or expression of the alpha-subunit of G, encoded by the complex locus, are responsible for several human diseases for which the clinical findings result, at least partly, from aberrant PTH signaling. Here, we review the bone and renal actions of PTH with respect to the different signaling pathways downstream of these G proteins, as well as the disorders caused by mutations.

Authors : Bastepe Murat, Turan Serap, He Qing,



(6) Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs in Osteoporosis Therapy.[TOP]

Pubmed ID :28303448
Publication Date : //
The purpose is to review the efficacy and optimal use of parathyroid hormone and parathyroid hormone-related protein analogs in osteoporosis treatment.

Authors : Leder Benjamin Z,



(7) Serum NT-proBNP Levels Are Not Related to Vitamin D Status in Young Patients with Congenital Heart Defects.[TOP]

Pubmed ID :26955207
Publication Date : //
Hypovitaminosis D frequently occurs in early life and increases with age. Vitamin D has been suggested to influence cardiac performance and N-terminal-pro-type B natriuretic peptide (NT-proBNP) release in adults with heart failure.

Authors : Passeri E, Rigolini R, Costa E, Verdelli C, Arcidiacono C, Carminati M, Corbetta S,



(8) Relation of Age, Sex and Bone Mineral Density to Serum 25-Hydroxyvitamin D Levels in Chinese Women and Men.[TOP]

Pubmed ID :26791959
Publication Date : //
To investigate the relation of circulating 25-hydroxyvitamin D (25[OH]D) levels to age, sex, and bone mineral density (BMD) in adults living in Guangzhou Province.

Authors : Wei Qiu-shi, Chen Zhen-qiu, Tan Xin, Su Hai-rong, Chen Xiao-xiang, He Wei, Deng Wei-min,



(9) Comparative study of the effect of PTH (1-84) and strontium ranelate in an experimental model of atrophic nonunion.[TOP]

Pubmed ID :26521993
Publication Date : //
This study aimed to set up an experimental model of long bone atrophic nonunion and to explore the potential role of PTH-1-84 (PTH 1-84) and strontium ranelate (SrR). A model of atrophic nonunion was created in Sprague-Dawley rats at the femoral midshaft level. The animals were randomised into four groups. Group A1: control rodents, fracture without bone gap; Group A2: rodents with subtraction osteotomy (non-union model control) treated with saline; Group B: rodents with subtraction osteotomy treated with human-PTH (PTH 1-84); and Group C: rodents with subtraction osteotomy treated with strontium ranelate (SrR). The groups were followed for 12 weeks. X-rays were be obtained at weeks 1, 6 and 12. After sacrificing the animals, we proceeded to the biomechanical study and four point bending tests to evaluate the resistance of the callus and histological study. In second phase, the expression of genes related to osteoblast function was analysed by reverse transcription-quantitative PCR in rats subjected to substraction osteotomy and treated for 2 weeks. The animals were randomised into three groups: Group A2: rodents treated with saline; Group B: rodents treated with PTH 1-84 and Group C: rodents treated with SrR.

Authors : Pérez Núñez M I, Ferreño Blanco D, Alfonso Fernández A, Casado de Prado J A, Sánchez Crespo M, De la Red Gallego M, Pascual Carra A, Rodriguez López T, Diego Cavia S, Garcés Zarzalejo C, Mayorga Fernández M, Ruiz Martínez E, Carrascal Vaquero I, Riancho Moral J A,



(10) Voyages of Discovery.[TOP]

Pubmed ID :26138832
Publication Date : //
The metabolism of calcium and bone is controlled by five principal hormones: parathyroid hormone, 1,25-dihydroxyvitamin D, calcitonin, parathyroid hormone-related peptide and fibroblast growth factor 23, some of which have been known for several decades and some of which have only more recently been identified. The stories of the discovery of these hormones have constituted a series of complex journeys that have been undertaken over the past century or so, none of which has yet been completed. The complexities of bone and calcium metabolism have been and remain, to many people, somewhat mysterious and a daunting task to understand. This book is designed to try to unravel those mysteries and present them in an interesting and comprehensible manner.

Authors : Allgrove Jeremy,