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Endocrine Markers: Cortisol ELISA (Sheep)

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[#CO116S-400] Endocrine Markers: Cortisol ELISA (Sheep)

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CO116S-400 | Endocrine Markers: Cortisol ELISA (Sheep), 1 Kit
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(1) Competition stage influences perceived performance but does not affect rating of perceived exertion and salivary neuro-endocrine-immune markers in elite young basketball players.[TOP]

Pubmed ID :29425971
Publication Date : //
This study examined the effects of competition stage on the salivary concentration of testosterone (T), cortisol (C), alpha-amylase (sAA), and IL-1ß cytokine, perceived performance (PP) and session rating of perceived exertion (session-RPE) in elite youth basketball players (age, 15.8 ± 0.8 yrs.; stature, 190.9 ± 7.9 cm; body mass, 90.0 ± 16.9 kg) from two age-categories (U16; n = 7; U17; n = 7). Two winning playoff matches (FM; playing for the championship; 1 for each age-category) and two winning regular stage matches (RM; 1 for each age category, played against opponents ranked 2nd place), were assessed in the current study. Saliva samples were collected before and after each match and analyzed by ELISA; PP and session-RPE were assessed after each match. The results from the two-way ANOVA (condition; FM and RM) with repeated measures (pre-and post-matches) showed a significant effect for time (increase from pre-to-post matches) in T (F = 7.0, p < .001), C (F = 34.0, p < .001), and sAA (F = 25.0, p < .001), but not for IL-1ß (p > .05). No effect of condition or interaction (FM and RM) was observed on salivary markers. PP was higher for FM, compared to RM (effect size; ES = 0.85), despite no clear difference in session-RPE (ES = 0.22). A higher PP for FM might be associated with the fact that players were no longer concerned about issues linked to social dominance and status threats after FM, but they might be uncertain about their status after RM. Additionally, when playing against a high-level opponent, the players might perceive their opponent as a threat against status stability, regardless of the stage of the competition, which might explain the similar change in salivary neuro-endocrine-immune-related markers.

Authors : Arruda Ademir Felipe Schultz de, Aoki Marcelo Saldanha, Paludo Ana Carolina, Drago Gustavo, Moreira Alexandre,



(2) Role of olfactory reactions, nociception, and immunoendocrine shifts in addictive disorders.[TOP]

Pubmed ID :28782904
Publication Date : //
Addictive pathology is associated with nervous, immune, and endocrine shifts. Meanwhile, the nature of intersystemic relationship lying beneath addictive disorders remains unclear. The purpose of the study was to identify neuroimmunoendocrine markers of addictive disorders in male subjects defining the nature of their interaction.

Authors : Masterova Elena, Nevidimova Tatiana, Savochkina Dariya, Nikitina Valentina, Lobacheva Olga, Vetlugina Tamara, Bokhan Nikolay,



(3) Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis.[TOP]

Pubmed ID :27403034
Publication Date : //
The adrenal glands are able to modulate immune responses through neuroimmunoendocrine interactions and cortisol secretion that could suppress exacerbated inflammation such as in inflammatory bowel disease (IBD). Therefore, here we evaluated the role of these glands in experimental colitis induced by 3% dextran sulfate sodium (DSS) in C57BL/6 mice subjected to adrenalectomy, with or without glucocorticoid (GC) replacement. Mice succumbed to colitis without adrenals with a higher clinical score and augmented systemic levels of IL-6 and lower LPS. Furthermore, adrenalectomy negatively modulated systemic regulatory markers. The absence of adrenals resulted in augmented tolerogenic lamina propria dendritic cells but no compensatory local production of corticosterone and decreased mucosal inflammation associated with increased IFN-γ and FasL in the intestine. To clarify the importance of GC in this scenario, GC replacement in adrenalectomized mice restored different markers to the same degree of that observed in DSS group. Finally, this is the first time that adrenal-derived hormones, especially GC, were associated with the differential local modulation of the gut infiltrate, also pointing to a relationship between adrenalectomy and the modulation of systemic regulatory markers. These findings may elucidate some neuroimmunoendocrine mechanisms that dictate colitis outcome.

Authors : de Souza Patrícia Reis, Sales-Campos Helioswilton, Basso Paulo José, Nardini Viviani, Silva Angelica, Banquieri Fernanda, Alves Vanessa Beatriz Freitas, Chica Javier Emílio Lazo, Nomizo Auro, Cardoso Cristina Ribeiro de Barros,



(4) ENDOCRINE AND METABOLIC ALTERATIONS MAY UNDERLIE MORTALITY OF SEVERE SEPSIS AND SEPTIC SHOCK PATIENTS ADMITTED TO ICU.[TOP]

Pubmed ID :27363046
Publication Date : //
The study evaluated endocrinal and metabolic response to sepsis and its applicability for the prediction of outcome of septic patients. Patients were 39 adult with severe infections and within 24 h after onset or suspected clinical tissue hypoperfusion. At enrollment patients were evaluated for acute physiology and chronic health evaluation II score (APACHE II) and Glasgow Coma Scale (GCS). Global hemodynamic parameters including systolic blood pressure (SBP), heart rate (HR) and central venous pressure (CVP) were recorded and monitored. All patients were managed at ICU due to Surviving Sepsis Campaign guidelines. ELISA estimated serum copeptin, macrophage migration inhibitory factor (MIF) and total cortisol (TC) and blood lactate levels. Study outcome was survival rate via 28 days (28-D SR) and best predictor for it. The results showed that 22 patients passed total hospital stay uneventfully for a total survival rate of 56.4%. Seventeen patients died; 10 during ICU stay and 7 during word stay. At admission serum markers levels were significantly higher in survivors and non-survivors compared to controls and in non-survivors compared to survivors. Survival showed negative significant correlation with age, high blood lactate and serum copeptin, TC and MIF levels. Survival showed positive significant correlation with SBP, CVP and urine output. ROC curve and Regression analyses defined high at admission serum copeptin and blood lactate levels as significant predictors for mortality of septic patients.

Authors : Ameen Abdelbadee, Abdel Rehim Marwa, Shaaban Yasser Hassan,



(5) The impact of an ultramarathon on hormonal and biochemical parameters in men.[TOP]

Pubmed ID :24931590
Publication Date : //
To examine circulating hormonal responses in men competing in the Western States Endurance Run (WSER, June 23 to 24, 2012): a 161-km trail run that starts in Squaw Valley, CA, and concludes in Auburn, CA.

Authors : Kupchak Brian R, Kraemer William J, Hoffman Martin D, Phinney Stephen D, Volek Jeff S,



(6) Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression.[TOP]

Pubmed ID :23089630
Publication Date : //
The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatly among individual studies. A potentially important factor explaining variability is heterogeneity of MDD. Aim of this study was to evaluate the association between depressive subtypes (based on latent class analysis) and biological measures. Data from 776 persons from the Netherlands Study of Depression and Anxiety, including 111 chronic depressed persons with melancholic depression, 122 with atypical depression and 543 controls were analyzed. Inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-α), metabolic syndrome components, body mass index (BMI), saliva cortisol awakening curves (area under the curve with respect to the ground (AUCg) and with respect to the increase (AUCi)), and diurnal cortisol slope were compared among groups. Persons with melancholic depression had a higher AUCg and higher diurnal slope compared with persons with atypical depression and with controls. Persons with atypical depression had significantly higher levels of inflammatory markers, BMI, waist circumference and triglycerides, and lower high-density lipid cholesterol than persons with melancholic depression and controls. This study confirms that chronic forms of the two major subtypes of depression are associated with different biological correlates with inflammatory and metabolic dysregulation in atypical depression and HPA-axis hyperactivity in melancholic depression. The data provide further evidence that chronic forms of depressive subtypes differ not only in their symptom presentation, but also in their biological correlates. These findings have important implications for future research on pathophysiological pathways of depression and treatment.

Authors : Lamers F, Vogelzangs N, Merikangas K R, de Jonge P, Beekman A T F, Penninx B W J H,



(7) Spectral and duration sensitivity to light-at-night in 'blind' and sighted rodent species.[TOP]

Pubmed ID :21900468
Publication Date : //
Light-at-night (LAN) has become a defining feature of human and animal ecosystems and may possibly compromise human and animal physiology and health. Spectral and acclimation duration (AD) sensitivity were compared between social voles (Microtus socialis) and 'blind' mole rats (Spalax ehrenbergi) in four increasing ADs (0, 1, 7 and 21 days) to LAN (1×30 min, 293 μW cm(-2)) of three different monochromatic lights [blue (479 nm), yellow (586 nm) and red (697 nm)]. Animals were sampled for urine and oxygen consumption (V(O(2))) promptly after each LAN-AD. Urine samples were analyzed for production rate, urinary 6-sulfatoxymelatonin and urinary metabolites of adrenalin and cortisol. Overall, the blue light elicited the greatest effects on the biological markers of M. socialis, whereas similar effects were detected for S. ehrenbergi in response to red light. The increasing LAN-AD resulted in a dose-dependent decrement of all markers tested, except of stress hormones, which showed a direct positive correlation with LAN-AD. Our results suggest that: (1) photoperiod is an important cue for entraining physiological functions in the 'blind' S. ehrenbergi, which is essentially characterized by red-shifted sensitivity compared with the blue-shifted sensitivity detected for the sighted counterpart species, and (2) there is a strong association between LAN of the appropriate wavelength and adrenal endocrine responses, suggesting that LAN is a potential environmental stressor.

Authors : Zubidat Abed E, Nelson Randy J, Haim Abraham,



(8) Inhaled fluticasone and the hormonal and inflammatory response to brief exercise.[TOP]

Pubmed ID :20308927
Publication Date : //
Inhaled corticosteroids (ICS) improve symptoms in lung diseases, such as asthma. Initial data suggest that the effects of ICS remain localized in the lung; however, recent studies demonstrate alteration to the peripheral immune system in patients with asthma. We sought to evaluate the effect of ICS on peripheral immune mediators and hypothalamic-pituitary-adrenal axis and their response to exercise in healthy men.

Authors : Schwindt Christina D, Zaldivar Frank, Eliakim Alon, Shin Hye-Won, Leu Szu-Yun, Cooper Dan M,



(9) Exercise intensity-dependent changes in the inflammatory response in sedentary women: role of neuroendocrine parameters in the neutrophil phagocytic process and the pro-/anti-inflammatory cytokine balance.[TOP]

Pubmed ID :19365147
Publication Date : //
It is still not really known what is the optimal level of exercise that improves, but does not impair or overstimulate the innate immune function. This is especially the case in women, who have higher basal levels of 'inflammatory markers' than men. The aim of this work was to evaluate differences in the magnitude of the stimulation of the innate/inflammatory response following a single bout of moderate or intense exercise in sedentary women, all of them in the follicular phase of their menstrual cycle. Changes in stress and sexual hormones were also evaluated.

Authors : Giraldo E, Garcia J J, Hinchado M D, Ortega E,



(10) Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques.[TOP]

Pubmed ID :18849121
Publication Date : //
Early stressful events can increase vulnerability for psychopathology, although knowledge on the effectors is still limited. Here we tested the hypothesis that peripheral levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are involved in the response to stress and in the pathophysiology of anxiety and depression, might be affected in a non-human primate model of adverse rearing. Males and females rhesus macaques reared with their mothers (MR) or in peer-only groups (PR) were used as experimental subjects. BDNF, NGF, adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA and RIA procedures. In addition, behavior was assessed on PND 7, 14, 21, 30 (Brazelton test) and 60 (home cage observation). Data indicate gender differences in basal levels of BDNF throughout development. Peer-rearing increased significantly BDNF levels only in females. In addition, while all peer-reared subjects showed high levels of stereotypies and self-directed behaviors, behavioral passivity was selectively increased in females. By contrast, NGF levels were increased in response to peer-rearing only in males, and correlated positively with other "classic" endocrine responses to stress, such as cortisol and GH. Our data identify BDNF and NGF as neuroendocrine markers underlying differential responses to maternal deprivation in males and females rhesus macaques. The selective changes in BDNF levels in females could help explain the greater vulnerability to mood disorders of this gender reported in humans.

Authors : Cirulli Francesca, Francia Nadia, Branchi Igor, Antonucci Maria Teresa, Aloe Luigi, Suomi Stephen J, Alleva Enrico,