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GLUT 1 (Glucose Transporter), Hep G2 type Transporter, 42_45 kD, Rabbit anti_Human, Mouse, Rat, Rabbit; WB_IP_ELISA

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[#OBT1747] GLUT 1 (Glucose Transporter), Hep G2 type Transporter, 42_45 kD, Rabbit anti_Human, Mouse, Rat, Rabbit; WB_IP_ELISA


OBT1747 | GLUT 1 (Glucose Transporter), Hep G2 type Transporter, 42_45 kD, Rabbit anti_Human, Mouse, Rat, Rabbit; WB_IP_ELISA, 50 µg.
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(1) Leptin and its receptor in glucose metabolism of T-cell lymphoma.[TOP]

Pubmed ID :30333864
Publication Date : //
T-cell lymphoma (TCL) is a group of heterogeneous disorders with a poor response to conventional treatment. In order to identify novel therapeutic targets, the present study investigated the effect of leptin and its receptor on glucose metabolism in TCL. The expression of the leptin receptor (ObR), and glucose transporter (Glut)1 and 4 was detected in TCL and reactive lymphoid hyperplasia (RLH) tissues by immunohistochemical analysis. A higher level of ObR expression was observed in the TCL tissues than in the RLH tissues (58.3 vs. 22.2%; P=0.012), and ObR overexpression was associated with high expression of Glut1 (P=0.007). analysis using the human TCL MOLT-3 cell line demonstrated that leptin stimulated cell glucose uptake via promoting recruitment and expression of Glut1, effects which were abolished by ObR-specific small interfering RNA (siRNA). Additionally, MOLT-3 cell viability was also increased following leptin treatment. ObR-specific siRNA abolished these responses. In conclusion, these results suggested that leptin serves a critical role in TCL glucose uptake via the ObR.

Authors : Han Tian-Jie, Xu Hong-Zhi, Li Jun-Shan, Geng Ling-Yun, Li Xin-Yu, Zhou Xiang-Xiang, Wang Xin,

(2) Allyl methyl sulfide, a garlic active component mitigates hyperglycemia by restoration of circulatory antioxidant status and attenuating glycoprotein components in streptozotocin-induced experimental rats.[TOP]

Pubmed ID :30318971
Publication Date : //
Diabetes is a major non-communicable life threatening chronic and pervasive condition that is consuming the world health in a petrifying rate. The circulatory system is one of the major sources of hyperglycemia induced ROS generation. Historically, garlic has been revered as part of a healthful diet. Organosulfur compounds have been attributed to the medicinal properties and health benefits of garlic. The present study focuses on the ameliorative role of Allyl methyl sulfide (AMS) in combating diabetic complications in diabetic rats. Male Wistar rats were randomly divided into four groups. Experimental diabetes was induced by a single intraperitoneal injection (i.p), of streptozotocin (STZ) (40 mg/kg b.w). STZ treated diabetic rats showed significant augment in plasma glucose level, lipidperoxidative (LPO) markers, glycoprotein components (hexose, hexosamine, sialic acid and fucose) and significant decline in plasma insulin level, non enzymatic antioxidants and activities of antioxidant enzymes in the circulatory system and tissues. Further, periodic acid-Schiff (PAS) staining of hepatic and renal tissues revealed positive stain accumulation and western blot investigation of glucose transporter 2 (GLUT 2) in pancreas of STZ-induced hyperglycemic rats. Dietary intervention with AMS (100 mg/kg b.w) for 30 days demonstrated significant protective effects on all the biochemical parameters studied. Besides, biochemical findings were corroborated by histological exertion and western blot study. The findings of current investigations recommended that AMS can ameliorate the consequences of diabetes due to their antioxidant efficacy and can be used as a potential therapeutic approach. Further studies are warranted to explore the clinical application of AMS.

Authors : Sujithra Kathiroli, Subramani Srinivasan, Dhananjayan Indumathi, Vinothkumar Veerasamy,

(3) Multifocal congenital pyogenic granuloma successfully treated with oral propranolol.[TOP]

Pubmed ID :30318648
Publication Date : //
Disseminated congenital pyogenic granuloma (DCPG) is an uncommon condition. Individual lesions of DCPG share clinical and histologic similarities with infantile hemangioma (IH); endothelial glucose transporter 1 (GLUT-1), which is highly expressed in IH but generally not in pyogenic granulomas (PG), is an important diagnostic tool. Treatment for DCPG remains difficult. We describe a case of DCPG effectively treated with propranolol.

Authors : Alharbi Mana, Eber Ariel E, Perper Marina, ALFalah Maisa, Al-Khenaizan Sultan, Alomair Ibrahim A, Alfuraih Abdulkareem, Nouri Keyvan, Cho-Vega Jeong Hee,

(4) MiR-1204 promotes ovarian squamous cell carcinoma growth by increasing glucose uptake.[TOP]

Pubmed ID :30304996
Publication Date : //
MiR-1204 has been recently identified as an oncogenic miRNA in breast cancer. Our study aims to investigate the role of miR-1204 in ovarian squamous cell carcinoma. Expression of miR-1204 and glucose transporter 1 in ovarian biopsies and plasma of both OC patients and healthy controls was detected by qRT-PCR. Correlations between patients' clinicopathological data were analyzed by Chi-square test. MiR-1204 overexpression OC cell lines were established. Expression of GLUT-1 protein was detected by western blot. Glucose uptake was measured by glucose uptake assay. Cell proliferation was detected by CCK-8 assay. We found that miR-1204 expression was significantly correlated with tumor size. Expression levels of miR-1204 and GLUT-1 were significantly high in OC patients. Expression levels of miR-1204 were positively correlated with expression levels of GLUT-1 in OC patients. MiR-1204 overexpression significantly promoted GLUT-1 expression, glucose uptake and cell proliferation. MiR-1204 may promote ovarian squamous cell carcinoma growth by increasing glucose uptake.

Authors : Xu Jia, Gu XiaoLi, Yang Xiaozhuo, Meng Yuejin,

(5) A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats.[TOP]

Pubmed ID :30285704
Publication Date : //
A substantial literature supports antidiabetic properties of the lanosteryl triterpene (methyl-3β-hydroxylanosta-9,24-dien-21-oate, RA-3) isolated from Protorhus longifolia stem bark. However, the molecular mechanism(s) associated with the antihyperglycemic properties of the triterpene remained to be explored. The current study aimed at investigating the molecular mechanism(s) through which RA-3 improves insulin signaling in streptozotocin-induced type 1 diabetic rats.

Authors : Ephraim Mabhida Sihle, Rabia Johnson, Musawenkosi Ndlovu, Felicia Sangweni Nonhlakanipho, Johan Louw, Andrew Opoku, Anthony Mosa Rebamang,

(6) Rare and Treatable Cause of Early-Onset Refractory Absence Seizures.[TOP]

Pubmed ID :30271476
Publication Date : //
Glut-1 transporter deficiency syndrome (GLUT1-DS) is a rare disorder caused by the mutation in SLC2A1 gene, which results in impaired glucose transport into the brain. It has a broad spectrum of phenotypic presentation ranging from cognitive decline, microcephaly, and refractory seizures to complex movement disorder. Recognition of this disorder is necessary as it is refractory to antiepileptic drugs (AEDs) and responds significantly to ketogenic diet. We report a case of 7-year-old girl who presented with paroxysmal eye movements in infancy with early-onset absence epilepsy (EOAE), which worsened in early morning and on fasting and was found to be refractory to four AEDs. She had mild developmental delay and subtle ataxia. Cerebrospinal fluid showed hypoglycorrhachia, and molecular analysis identified deletion in exon 4 of SLC2A1 gene (p.leu169del), thus confirming GLUT1-DS. She had a near-complete seizure control on ketogenic diet. Thus, GLUT1-DS should be suspected in all cases of refractory generalized seizures specially EOAE, especially if it worsens on fasting, is associated with development delay, positive family history, or paroxysmal movement disorder.

Authors : Panandikar Gajanan A, Ravat Sangeeta H, Ansari Rahil R, Desai Karan M,

(7) Human cellular mitochondrial remodelling is governed by miR-2909 RNomics.[TOP]

Pubmed ID :30252847
Publication Date : //
There exists a general recognition of the fact that mitochondrial remodelling as a result of aerobic glycolysis ensures human somatic cells to revert to a more primitive-form exhibiting stem-like phenotype. The present study is an attempt to demonstrate that miR-2909 RNomics within human peripheral blood mononuclear cells (PBMCs) has the inherent capacity to re-program these cells to exhibit mitochondrial remodelling paralleled by aerobic glycolysis together with intracellular lipid inclusions. Such re-programmed PBMCs also expressed genes having ability to sustain their de-differentiation state and survival.

Authors : Malik Deepti, Kaul Deepak,

(8) Effect of the Shensong Yangxin Capsule on Energy Metabolism in Angiotensin II-Induced Cardiac Hypertrophy.[TOP]

Pubmed ID :30246714
Publication Date : //
Shensong Yangxin Capsule (SSYX), traditional Chinese medicine, has been used to treat arrhythmias, angina, cardiac remodeling, cardiac fibrosis, and so on, but its effect on cardiac energy metabolism is still not clear. The objective of this study was to investigate the effects of SSYX on myocardium energy metabolism in angiotensin (Ang) II-induced cardiac hypertrophy.

Authors : Liu Bei-Lei, Cheng Mian, Hu Shan, Wang Shun, Wang Le, Hu Zheng-Qing, Huang Cong-Xin, Jiang Hong, Wu Gang,

(9) Hypoxia Imaging and Biological Evaluation of the Radiosensitizing Effect of Oleanolic Acid.[TOP]

Pubmed ID :30246018
Publication Date : //
The aim of this study was to evaluate the radiosensitizing effect of oleanolic acid (OA) on C6 rat glioma and the changes in tumor biology during radiosensitization therapy on F-fluoromisonidazole (F-FMISO) positron emission tomography/computed tomography (PET/CT).

Authors : Wang Hui, Zhang Yu, Yu Wenjing, Xue Yangyang, Xiao Liang, Xu Huiqin,

(10) Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds.[TOP]

Pubmed ID :30245467
Publication Date : //
In this study, we synthesized five N-Boc-L-tyrosine-based analogues to glitazars. The in vitro effects of compounds 1-5 on protein tyrosine phosphatase 1B (PTP-1B), peroxisome proliferator-activated receptor alpha and gamma (PPARα/γ), glucose transporter type-4 (GLUT-4) and fatty acid transport protein-1 (FATP-1) activation are reported in this paper. Compounds 1 and 3 were the most active in the in vitro PTP-1B inhibition assay, showing ICs of approximately 44 μM. Treatment of adipocytes with compound 1 increased the mRNA expression of PPARγ and GLUT-4 by 8- and 3-fold, respectively. Moreover, both compounds (1 and 3) also increased the relative mRNA expression of PPARα (by 8-fold) and FATP-1 (by 15-fold). Molecular docking studies were performed in order to elucidate the polypharmacological binding mode of the most active compounds on these targets. Finally, a murine model of hyperglycemia was used to evaluate the in vivo effectiveness of compounds 1 and 3. We found that both compounds are orally active using an exploratory dose of 100 mg/kg, decreasing the blood glucose concentration in an oral glucose tolerance test and a non-insulin-dependent diabetes mellitus murine model. In conclusion, we demonstrated that both molecules showed strong in vitro and in vivo effects and can be considered polypharmacological antidiabetic candidates.

Authors : Herrera-Rueda Miguel Ángel, Tlahuext Hugo, Paoli Paolo, Giacoman-Martínez Abraham, Almanza-Pérez Julio César, Pérez-Sánchez Horacio, Gutiérrez-Hernández Abraham, Chávez-Silva Fabiola, Dominguez-Mendoza Elix Alberto, Estrada-Soto Samuel, Navarrete-Vazquez Gabriel,