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GLUT 1 (Glucose Transporter), Hep G2 type Transporter, 42_45 kD, Rabbit anti_Human, Mouse, Rat, Rabbit; WB_IP_ELISA

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[#OBT1747] GLUT 1 (Glucose Transporter), Hep G2 type Transporter, 42_45 kD, Rabbit anti_Human, Mouse, Rat, Rabbit; WB_IP_ELISA


OBT1747 | GLUT 1 (Glucose Transporter), Hep G2 type Transporter, 42_45 kD, Rabbit anti_Human, Mouse, Rat, Rabbit; WB_IP_ELISA, 50 µg.
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(1) Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review.[TOP]

Pubmed ID :30105479
Publication Date : //
This systematic review describes evidence concerning medicinal plants that, in addition to exerting hypoglycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension, and/or hyperlipidemia among individuals with diabetes mellitus (DM).

Authors : Nazarian-Samani Zeinab, Sewell Robert D E, Lorigooini Zahra, Rafieian-Kopaei Mahmoud,

(2) Fructose and prostate cancer: toward an integrated view of cancer cell metabolism.[TOP]

Pubmed ID :30104655
Publication Date : //
Activation of glucose transporter-1 (Glut-1) gene expression is a molecular feature of cancer cells that increases glucose uptake and metabolism. Increased glucose uptake is the basis for the clinical localization of primary tumors using positron emission tomography (PET) and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) as a radiotracer. However, previous studies have demonstrated that a considerable number of cancers, which include prostate cancer (CaP), express low to undetectable levels of Glut-1 and that FDG-PET has limited clinical applicability in CaP. This observation could be explained by a low metabolic activity of CaP cells that may be overcome using different hexoses, such as fructose, as the preferred energy source. However, these hypotheses have not been examined critically in CaP. This review article summarizes what is currently known about transport and metabolism of hexoses, and more specifically fructose, in CaP and provides experimental evidences indicating that CaP cells may have increased capacity to transport and metabolize fructose in vitro and in vivo. Moreover, this review highlights recent findings that allow better understanding of how metabolism of fructose may regulate cancer cell proliferation and how fructose uptake and metabolism, through the de novo lipogenesis pathway, may provide new opportunities for CaP early diagnosis, staging, and treatment.

Authors : Carreño Daniela, Corro Néstor, Torres-Estay Verónica, Véliz Loreto P, Jaimovich Rodrigo, Cisternas Pedro, San Francisco Ignacio F, Sotomayor Paula C, Tanasova Marina, Inestrosa Nibaldo C, Godoy Alejandro S,

(3) Pioglitazone induces hypoxia-inducible factor 1 activation in human renal proximal tubular epithelial cell line HK-2.[TOP]

Pubmed ID :30057316
Publication Date : //
We previously reported that fatty acid-bearing albumin but not fatty acid-depleted albumin induces hypoxia-inducible factor-1 (HIF-1) activation in human renal proximal tubular epithelial cell line HK-2. Then, an increase in mRNA expression of peroxisome proliferator-activated receptor gamma (PPARγ) was observed on treatment with fatty acid-bearing albumin but not fatty acid-depleted albumin. The aim of this study was to determine whether a PPARγ agonist, pioglitazone, induces HIF-1 activation or not. Treatment with pioglitazone induced HIF-1α mRNA as well as PPARγ mRNA expression in a concentration dependent manner. In addition, pioglitazone increased HIF-1 target genes such as the mRNAs of glucose transporter 1 (GLUT1) and breast cancer resistance protein (BCRP/ABCG2), in a concentration-dependent manner. Consistent with the increases in GLUT1 and ABCG2 mRNAs, protein expression of GLUT1 and BCRP was increased by pioglitazone. In addition, GLUT inhibitor phloretin-sensitive D-[H]glucose uptake activity and BCRP inhibitor Ko143-sensitive accumulation of Hoecsht33342, a BCRP substrate, were significantly enhanced by treatment with pioglitazone. These findings suggest that PPARγ activation by pioglitazone leads to HIF-1 protein expression induction followed by changes in HIF-1 target gene expression and protein product activity.

Authors : Urakami-Takebayashi Yumiko, Kuroda Yukimi, Murata Tadashi, Miyazaki Makoto, Nagai Junya,

(4) Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat.[TOP]

Pubmed ID :30050409
Publication Date : //
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and that its administration to neurons suffering from trauma or disease is able to rescue them from cell death. We questioned whether VEGF could also maintain damaged neurons in a neurotransmissive mode by evaluating the synthesis of their neurotransmitter, and whether its action would be direct or through its well-known angiogenic activity. Adult rat extraocular motoneurons were chosen as the experimental model. Lesion was performed by monocular enucleation and immediately a gelatine sponge soaked in VEGF was implanted intraorbitally. After 7 days, abducens, trochlear, and oculomotor nuclei were examined by immunohistochemistry against choline acetyltransferase (ChAT), the biosynthetic enzyme of the motoneuronal neurotransmitter acetylcholine. Lesioned motoneurons exhibited a noticeable ChAT downregulation which was prevented by VEGF administration. To explore whether this action was mediated via an increase in blood vessels or in their permeability, we performed immunohistochemistry against laminin, glucose transporter-1 and the plasmatic protein albumin. The quantification of the immunolabeling intensity against these three proteins showed no significant differences between VEGF-treated, axotomized and control animals. Therefore, the present data indicate that VEGF is able to sustain the cholinergic phenotype in damaged motoneurons, which is a first step for adequate neuromuscular neurotransmission, and that this action seems to be mediated directly on neurons since no sign of angiogenic activity was evident. These data reinforces the therapeutical potential of VEGF in motoneuronal diseases.

Authors : Acosta Lourdes, Morcuende Sara, Silva-Hucha Silvia, Pastor Angel M, de la Cruz Rosa R,

(5) Hypoglycemic activity and constituents analysis of blueberry () fruit extracts.[TOP]

Pubmed ID :30046248
Publication Date : //
To investigate hypoglycemic activity and elucidate the active composition of the fruit blueberry ().

Authors : Huang Weifeng, Yao Liangliang, He Xiao, Wang Lei, Li Mingxi, Yang Youxin, Wan Chunpeng,

(6) Diagnostic Value of Glucose Transporter 1 (GLUT-1) Expression in Nested Variant of Urothelial Carcinoma.[TOP]

Pubmed ID :30035295
Publication Date : //
Nested variant is bland-looking but aggressive subtype of urothelial carcinoma (UC). Cases having significant muscle invasion do not cause problems but small and superficial biopsies may be challenging due to morphological similarities between nested variant urothelial carcinoma and benign urothelial lesions.

Authors : Boyaci Ceren, Behzatoğlu Kemal,

(7) Characterization of a Novel Mitochondrial Ascorbate Transporter From Rat Liver and Potato Mitochondria.[TOP]

Pubmed ID :29998111
Publication Date : //
The Mitochondrial Ascorbic Acid Transporter (MAT) from both rat liver and potato mitochondria has been reconstituted in proteoliposomes. The protein has a molecular mass in the range of 28-35 kDa and catalyzes saturable, temperature and pH dependent, unidirectional ascorbic acid transport. The transport activity is sodium independent and it is optimal at acidic pH values. It is stimulated by proton gradient, thus supporting that ascorbate is symported with H. It is efficiently inhibited by the lysine reagent pyridoxal phosphate and it is not affected by inhibitors of other recognized plasma and mitochondrial membranes ascorbate transporters GLUT1(glucose transporter-1) or SVCT2 (sodium-dependent vitamin C transporter-2). Rat protein catalyzes a cooperative ascorbate transport, being involved two binding sites; the measured K is 1.5 mM. Taking into account the experimental results we propose that the reconstituted ascorbate transporter is not a GLUT or SVCT, since it shows different biochemical features. Data of potato transporter overlap the mammalian ones, except for the kinetic parameters non-experimentally measurable, thus supporting the MAT in plants fulfills the same transport role.

Authors : Scalera Vito, Giangregorio Nicola, De Leonardis Silvana, Console Lara, Carulli Emanuele Salvatore, Tonazzi Annamaria,

(8) True hypopharyngeal carcinosarcoma: a case report and literature review.[TOP]

Pubmed ID :29996673
Publication Date : //
Objective Carcinosarcoma consists of carcinomatous and sarcomatous tissues and is an aggressive malignant tumor. It is rarely reported in the hypopharynx. Methods A 72-year-old man presented with dysphagia and dyspnea. Laryngoscopy, computed tomography (CT), and F-fluorodeoxyglucose positron emission tomography/CT (F-FDG PET/CT) showed a neoplasm on the left posterior hypopharyngeal wall. The patient underwent bilateral neck dissection and excision of the hypopharyngeal cancer followed by postoperative radiation therapy. Results Immunohistochemistry revealed carcinomatous cells with membrane positivity for cytokeratin, glucose transporter-1 (GLUT-1), phosphoinositide-3 kinase (PI3K), hypoxia-inducible factor-1α (HIF-1α), and hexokinase-II as well as sarcomatous cells with membrane positivity for smooth muscle actin, GLUT-1, HIF-1α, and PI3K. Histopathology and immunohistochemistry revealed a true carcinosarcoma of the hypopharynx (pT3N0M0, Stage III). Conclusions Thorough immunohistochemistry is required for a correct diagnosis of hypopharyngeal carcinosarcoma. F-FDG PET/CT may help to distinguish hypopharyngeal carcinosarcoma from benign tumors.

Authors : Zhong Jiang-Tao, Xie Xiao-Xing, Zhou Shui-Hong, Yao Hong-Tian, Chen Zhe, Wu Ting-Ting, Bao Yang-Yang, Yu Qi, Han He-Ming,

(9) Comparative assessment of metal-specific adipogenic activity in zinc and vanadium-citrates through associated gene expression.[TOP]

Pubmed ID :29966853
Publication Date : //
Diabetes mellitus comprises a group of metabolic abnormalities due to insulin deficiency and/or resistance. Obesity contributes to diabetes, with a strong causal relationship existing between diabetes and insulin resistance, especially in patients with Diabetes mellitus II. Adipocytes emerge as key constituents of adipose tissue physiology. In their pre-mature form to mature state transformation, adipocytes fully exemplify one of the key adipogenic actions of insulin. Poised to a) gain insight into adipogenesis leading to antidiabetic factors, and b) investigate adipogenesis through careful examination of insulin contributions to interwoven mechanistic pathways, a systematic comparative study was launched involving well-defined metal-citrates (zinc and vanadium), the chemical reactivity of which was in line with their chemistry under physiological conditions. Selection of the specific compounds was based on their common aqueous coordination chemistry involving the physiological chelator citric acid. Cellular maturation of pre-adipocytes to their mature form was pursued in the presence-absence of insulin and employment of closely linked genetic targets, key to adipocyte maturation (Peroxisome proliferator-activated receptor gamma (PPAR-γ), Glucose transporter 1,3,4 (GLUT 1,3,4), Adiponectin (ADIPOQ), Glucokinase (GCK), and Insulin receptor (INS-R)). The results show a) distinct adipogenic biological profiles for the metalloforms involved in a dose-, time- and nature-dependent manner, and b) metal ion-specific adipogenic response-signals at the same or higher level than insulin toward all selected targets. Collectively, the foundations have been established for future exploitation of the distinct metal-specific adipogenic factors contributing to the functional maturation of adipose tissue and their use toward hyperglycemic control in Diabetes mellitus.

Authors : Tsave O, Yavropoulou M P, Kafantari M, Gabriel C, Yovos J G, Salifoglou A,

(10) Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells.[TOP]

Pubmed ID :29930982
Publication Date : //

Authors : Zhang Qin, Jeppesen Dennis K, Higginbotham James N, Demory Beckler Michelle, Poulin Emily J, Walsh Alex J, Skala Melissa C, McKinley Eliot T, Manning H Charles, Hight Matthew R, Schulte Michael L, Watt Kimberly R, Ayers G Daniel, Wolf Melissa M, Andrejeva Gabriela, Rathmell Jeffrey C, Franklin Jeffrey L, Coffey Robert J,