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Gc_Globulin, Vitamin D_Binding Protein, Clone 249_05, Mab anti_Human; ELISA

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[#HYB249-05] Gc_Globulin, Vitamin D_Binding Protein, Clone 249_05, Mab anti_Human; ELISA


HYB249-05 | Gc_Globulin, Vitamin D_Binding Protein, Clone 249_05, Mab anti_Human; ELISA, 200 µg.
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(1) Vitamin D Status Is Not Associated with Risk of Early Menopause.[TOP]

Pubmed ID :30107585
Publication Date : //
Early natural menopause, the cessation of ovarian function before age 45 y, is positively associated with cardiovascular disease and other conditions. Dietary vitamin D intake has been inversely associated with early menopause; however, no previous studies have evaluated risk with regard to plasma 25-hydroxyvitamin D [25(OH)D] concentrations.

Authors : Purdue-Smithe Alexandra C, Whitcomb Brian W, Manson JoAnn E, Hankinson Susan E, Troy Lisa M, Rosner Bernard A, Bertone-Johnson Elizabeth R,

(2) The Vitamin D Binding Protein axis modifies disease severity in Lymphangioleiomyomatosis.[TOP]

Pubmed ID :30093573
Publication Date : //
Lymphangioleiomyomatosis (LAM) is a rare disease of women. Decline in lung function is variable making appropriate targeting of therapy difficult. We used unbiased serum proteomics to identify markers associated with outcome in LAM. 101 women with LAM and 22 healthy controls were recruited from the National Centre for LAM (Nottingham, UK). 152 DNA and serum samples with linked lung function and outcome data were obtained from patients in the NHLBI LAM Registry (USA). Proteomic analysis was performed on a discovery cohort of 50 LAM and 20 control sera using a SCIEX SWATH mass spectrometric workflow. Protein levels were quantitated by ELISA and SNPs in encoding Vitamin D Binding Protein (VTDB) genotyped. Proteomic analysis showed VTDB was 2.6 fold lower in LAM than controls. Serum VTDB was lower in progressive compared with stable LAM (p=0.001) and correlated with diffusing capacity (p=0.01). Median time to death or lung transplant was reduced by 46 months in those with genotypes at rs4588 and 38 months in those with non-A containing haplotypes at rs7041/4588 (p=0.014 and 0.008 respectively). The VTDB axis is associated with disease severity and outcome, and genotype could help predict transplant free survival in LAM.

Authors : Miller Suzanne, Coveney Clare, Johnson Janice, Farmaki Aliki-Eleni, Gupta Nishant, Tobin Martin D, Wain Louise V, McCormack Francis X, Boocock David J, Johnson Simon R,

(3) Association of vitamin D binding protein and vitamin D receptor gene polymorphisms in Iranian patients with chronic periodontitis.[TOP]

Pubmed ID :30083974
Publication Date : //
Chronic periodontitis (CP) is a multifactorial disease and the most common type of periodontitis mainly caused by microbial plaque. Insufficient oral hygiene may initiate CP and it can be further modified and progressed by environmental and genetic susceptibilities. The aim of the present study was to investigate the association between VDBP (rs7041 and rs4588) and (Taq 1-rs7975232 and Apa1-rs731236) SNPs of VDR gene receptor and susceptibility to CP in an Iranian population. Sixty nine cases with diagnosis of CP and 78 matched healthy controls engaged in this study. Three-milliliter peripheral blood samples were obtained for DNA isolation. Genotype analysis was performed using restriction fragment length polymorphism polymerase chain reaction (RFLP-PCR). Chi-squared test was used for distribution of genotypes analysis. 95% confidence interval (CI) was used to calculate the odds ratio (OR). Deviation from Hardy-Weinberg equilibrium, multiple inheritance models, linkage disequilibrium and haplotype analysis were done. There was no significant association between genotype/phenotype of VDBP's SNPs (rs7041 and rs4588) and occurrence of chronic periodontitis (p value = 0.401) Moreover, no statistically significant association was found between chronic periodontitis and Taq1 (rs731236) (p value = 0.401) and Apa1 (rs7975232) (p value = 0.248). The analysis of alleles and genotypes' distribution between different severities of chronic periodontitis and healthy controls indicated a significant association between various severities of chronic periodontitis and Apa1 (rs7975232) (p value = 0.011) and VDBP's SNPs (rs7041 and rs4588) (p value = 0.038), whereas no statistically significant association was observed between various severities of chronic periodontitis and Taq1 (rs731236) (p value = 0.278). Our results suggest a significant association between severity of chronic periodontitis and Apa1 (rs7975232) and VDBP SNPs (rs7041 and rs4588). Sequencing studies on different populations may release other results due to the genetic and racial diversity.

Authors : Nazemisalman Bahareh, Vahabi Surena, Sabouri Ehsan, Hosseinpour Sepanta, Doaju Sara,

(4) Effect of vitamin D supplementation on free and total vitamin D: a comparison of Asians vs Caucasians.[TOP]

Pubmed ID :30067874
Publication Date : //
It is well established that UK Asians typically have lower vitamin D levels than Caucasians. It is also known that vitamin D binding protein (DBP) is lower in some races than Caucasians. To investigate how ethnicity, skin colour and genetic variation affect the response to vitamin D (150,000 IU) administered to young Asian and Caucasian men.

Authors : Gopal-Kothandapani Jaya Sujatha, Evans Lucy Faith, Walsh Jennifer S, Gossiel Fatma, Rigby Alan S, Eastell Richard, Bishop Nick J,

(5) Vitamin D-binding protein is inversely associated with the incidence of gastrointestinal and ear infections in school-age children.[TOP]

Pubmed ID :30056817
Publication Date : //
Circulating 25-hydroxy vitamin D (25(OH)D) is related to decreased rates of gastrointestinal and ear infections in school-age children. Vitamin D-binding protein (DBP) transports 25(OH)D and exerts immunological functions; however, it is unknown whether DBP is associated with infectious morbidity in children. We quantified plasma DBP concentrations in 540 school-age children at the time of recruitment into a cohort study in Bogotá, Colombia and obtained daily information on infectious morbidity symptoms and doctor visits during the school year. We compared the incidence rates of gastrointestinal and respiratory symptoms across quartiles of DBP concentration by estimating adjusted incidence rate ratios (IRRs) with 95% confidence interval (CI). We also estimated the per cent of the associations between DBP and morbidity that were mediated through 25(OH)D using a counterfactual frame. Mean ± s.d. DBP concentration was 2650 ± 1145 nmol/l. DBP was inversely associated with the rates of diarrhoea with vomiting (IRR for quartiles 2-4 vs. 1 = 0.48; 95% CI 0.25-0.92; P = 0.03) and earache/ear discharge with fever (IRR for quartiles 2-4 vs. 1 = 0.29; 95% CI 0.12-0.71; P = 0.006). The DBP-morbidity associations were not mediated through 25(OH)D. We conclude that plasma DBP predicts lower incidence of gastrointestinal and ear infections in school-age children independent of 25(OH)D.

Authors : Palframan K M, Robinson S L, Mora-Plazas M, Marin C, Villamor E,

(6) The vitamin D paradox in Black Americans: a systems-based approach to investigating clinical practice, research, and public health - expert panel meeting report.[TOP]

Pubmed ID :30044889
Publication Date : //
The Office of Dietary Supplements, the National Institute on Minority Health and Health Disparities, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases, all components of the U.S. National Institutes of Health, co-sponsored an expert panel meeting to discuss the vitamin D paradox in Black Americans. The paradox is that despite markedly low (or "deficient") measures of vitamin D status in Black Americans, the incidence of falls, fractures, or osteopenia are significantly lower compared to White American counterparts with similar vitamin D status. Six panelists were invited to engage in guided discussions on the state of the science with respect to key knowledge gaps impacting vitamin D status and bone health. They were also asked to reflect on best approaches for advancing the science. A central theme throughout the discussions was that there may be many factors that impact Vitamin D levels in Black Americans and understanding these factors may be key to understanding mechanisms for improving bone health in all populations. Data presented showed that although adiposity, skin pigmentation, vitamin D binding protein polymorphisms, and genetics all contributed to differences in 25(OH)D levels in Black vs. White Americans, no one factor alone could fully explain the vitamin D paradox in Black Americans. However, the panelists did agree that the paradox is significant and warrants further investigation. There was consensus that Black Americans gained no skeletal benefits from high doses of vitamin D supplementation, and that high levels of the biomarker of vitamin D status, serum 25-hydroxyvitamin D or 25(OH)D, in this population are almost certain to result in adverse effects. Some panelists proposed that additional studies are needed so that the Institute of Medicine (IOM) can better define the safe upper limits of vitamin D intake in this and other subpopulations. Others suggested a need for better, more generalizable biomarkers of bone health to advance the science.

Authors : Brown LaVerne L, Cohen Barbara, Tabor Derrick, Zappalà Giovanna, Maruvada Padma, Coates Paul M,

(7) Vitamin D binding protein and risk of renal cell carcinoma in the Cancer Prevention Study-II Cohort.[TOP]

Pubmed ID :30030213
Publication Date : //
Kidney cancer has several well-established risk factors including smoking, obesity, and hypertension. These factors do not, however, completely account for its etiology. One previous study of vitamin D binding protein (DBP) and risk of renal cell carcinoma found a striking inverse association that warranted replication.

Authors : Mondul Alison M, Weinstein Stephanie J, Parisi Dominick, Um Caroline Y, McCollough Marjorie L, Albanes Demetrius,

(8) Vitamin D Supplementation and Survival of Patients with Non-small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial.[TOP]

Pubmed ID :30018118
Publication Date : //
Higher serum 25-hydroxyvitamin D (25(OH)D) levels are reportedly associated with better survival in early-stage non-small cell lung cancer (NSCLC). Therefore, whether vitamin D supplementation can improve the prognosis of patients with NSCLC was examined (UMIN000001869). A randomized, double-blind trial comparing vitamin D supplements (1,200 IU/day) with placebo for 1 year after operation was conducted. The primary and secondary outcomes were relapse-free survival (RFS) and overall survival (OS), respectively. Prespecified subgroup analyses were performed with stratification by stage (early vs. advanced), pathology (adenocarcinoma vs. others), and 25(OH)D levels (low, <20 ng/mL vs. high, ≥20 ng/mL). Polymorphisms of vitamin D receptor (VDR) and vitamin D-binding protein (DBP) and survival were also examined. Patients with NSCLC ( = 155) were randomly assigned to receive vitamin D ( = 77) or placebo ( = 78) and followed for a median of 3.3 years. Relapse and death occurred in 40 (28%) and 24 (17%) patients, respectively. In the total study population, no significant difference in either RFS or OS was seen with vitamin D compared with the placebo group. However, by restricting the analysis to the subgroup with early-stage adenocarcinoma with low 25(OH)D, the vitamin D group showed significantly better 5-year RFS (86% vs. 50%, = 0.04) and OS (91% vs. 48%, = 0.02) than the placebo group. Among the examined polymorphisms, DBP1 (rs7041) TT and CDX2 (rs11568820) AA/AG genotypes were markers of better prognosis, even with multivariate adjustment. In patients with NSCLC, vitamin D supplementation may improve survival of patients with early-stage lung adenocarcinoma with lower 25(OH)D levels.

Authors : Akiba Tadashi, Morikawa Toshiaki, Odaka Makoto, Nakada Takeo, Kamiya Noriki, Yamashita Makoto, Yabe Mitsuo, Inagaki Takuya, Asano Hisatoshi, Mori Shohei, Tsukamoto Yo, Urashima Mitsuyoshi,

(9) Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system.[TOP]

Pubmed ID :29999169
Publication Date : //
The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells. We revisited these hypotheses that were previously tested solely in the rodent models, this time using a 3-dimensional proximal tubule microphysiological system incorporating primary human proximal tubule epithelial cells. Using this human cell-derived model, we confirmed that 25OHD3 is transported into the human proximal tubule epithelium via megalin-mediated endocytosis while bound to vitamin D binding protein. Building upon these findings, we then evaluated the role of megalin in modulating the cellular uptake and biological activity of 1α,25(OH)2D3. Inhibition of megalin function decreased the 1α,25(OH)2D3-mediated induction of both cytochrome P450 24A1 protein levels and 24-hydroxylation activity following perfusion with vitamin D binding protein and 1α,25(OH)2D3. The potential for reciprocal effects from 1α,25(OH)2D3 on megalin expression were also tested. Contrary to previously published observations from rat proximal tubule epithelial cells, 1α,25(OH)2D3 did not induce megalin gene expression, thus highlighting the potential for meaningful interspecies differences in the homeostatic regulation of megalin in rodents and humans. These findings challenge a recently promoted hypothesis, predicated on the rodent cell data, that attempts to connect 1α,25(OH)2D3-mediated regulation of renal megalin expression and the pathology of chronic kidney disease in humans. In addition to providing specific insights related to importance of renal megalin in vitamin D homeostasis, these results constitute a proof-of-concept that human-derived microphysiological systems are a suitable replacement for animal models for quantitative pharmacology and physiology research.

Authors : Chapron Brian D, Chapron Alenka, Phillips Brian, Okoli Miracle C, Shen Danny D, Kelly Edward J, Himmelfarb Jonathan, Thummel Kenneth E,

(10) The Association Between Vitamin D Binding Protein Polymorphisms and Vitamin D Level on Epilepsy in China.[TOP]

Pubmed ID :29993274
Publication Date : //
Accumulating studies suggest the potential association between epilepsy and vitamin D (VD) in recent years. Vitamin D binding protein (VDBP) is the main VD carrier and can affect the availability of VD and its metabolites. Thus, this study aimed to investigate the association between VDBP polymorphisms and VD level on epilepsy. A total of 220 epilepsy patients and 210 health controls were enrolled and polymorphisms of VDBP (rs4588, rs7041, rs2298849, and rs2282679) genotype were detected using the PCR-ligase detection reaction method. The circulating status of VD metabolites, 25(OH)D and 24,25(OH)D, was detected by a validated high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method, and the VD metabolite ratio (VMR), 24,25(OH)D:25(OH)D, was then calculated. The frequency of rs4588(C>A) and rs2282679(A>C) genotype with AC was significantly lower among the patients relative to the controls [odds ratio, OR = 0.597, 95% confidence interval, CI = 0.401-0.890, p = 0.011 for rs4588(C>A); OR = 0.611, 95% CI = 0.409-0.912, p = 0.016 for rs2282679(A>C), respectively]. For rs7041 genotype distribution, VMR level was significantly higher in patients with GG genotype than in those carrying TT and TG genotype (p = 0.008). Our study demonstrated that the polymorphisms of VDBP rs4588 and rs2282679 may play a potentially important role in epilepsy susceptibility in Chinese Han population.

Authors : Wang Haidong, Guo Yujin, Li Gongying, Xie Ruining, Zhang Zhimei, Han Wenxiu, Yang Mengqi, Chen Dan, Jiang Pei,