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Gc_Globulin, Vitamin D_Binding Protein, Clone 249_05, Mab anti_Human; ELISA

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[#HYB249-05] Gc_Globulin, Vitamin D_Binding Protein, Clone 249_05, Mab anti_Human; ELISA


HYB249-05 | Gc_Globulin, Vitamin D_Binding Protein, Clone 249_05, Mab anti_Human; ELISA, 200 µg.
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(1) The Emerging Role of Nutritional Vitamin D in Secondary Hyperparathyroidism in CKD.[TOP]

Pubmed ID :30513912
Publication Date : //
In chronic kidney disease (CKD), hyperphosphatemia induces fibroblast growth factor-23 (FGF-23) expression that disturbs renal 1,25-dihydroxy vitamin D (1,25D) synthesis; thereby increasing parathyroid hormone (PTH) production. FGF-23 acts on the parathyroid gland (PTG) to increase 1α-hydroxylase activity and results in increase intra-gland 1,25D production that attenuates PTH secretion efficiently if sufficient 25D are available. Interesting, calcimimetics can further increase PTG 1α-hydroxylase activity that emphasizes the demand for nutritional vitamin D (NVD) under high PTH status. In addition, the changes in hydroxylase enzyme activity highlight the greater parathyroid 25-hydroxyvitmain D (25D) requirement in secondary hyperparathyroidism (SHPT); the higher proportion of oxyphil cells as hyperplastic parathyroid progression; lower cytosolic vitamin D binding protein (DBP) content in the oxyphil cell; and calcitriol promote vitamin D degradation are all possible reasons supports nutritional vitamin D (NVD; e.g., Cholecalciferol) supplement is crucial in SHPT. Clinically, NVD can effectively restore serum 25D concentration and prevent the further increase in PTH level. Therefore, NVD might have the benefit of alleviating the development of SHPT in early CKD and further lowering PTH in moderate to severe SHPT in dialysis patients.

Authors : Lu Chien-Lin, Yeih Dong-Feng, Hou Yi-Chou, Jow Guey-Mei, Li Zong-Yu, Liu Wen-Chih, Zheng Cai-Mei, Lin Yuh-Feng, Shyu Jia-Fwu, Chen Remy, Huang Chung-Yu, Lu Kuo-Cheng,

(2) Vitamin D binding protein, but not vitamin D or vitamin D-related peptides, is associated with septic shock mortality.[TOP]

Pubmed ID :30470461
Publication Date : //
The aim of this study was to assess the prognostic value of vitamin D, vitamin D binding protein (VDBP) and vitamin D-related peptides in septic shock patients in relation to hospital mortality.

Authors : Suberviola Borja, Lavin Bernardo Alio, Jimenez Andrés Fernando, Perez-San Martin Sonia, Garcia-Unzueta Maite, Santibañez Miguel,

(3) Adiponectin and vitamin D-binding protein concentrations are independently associated in apparently healthy women but not men: a validation cohort.[TOP]

Pubmed ID :30456750
Publication Date : //

Authors : Karras Spyridon N, Polyzos Stergios A, Tsekmekidou Xanthippi, Gerou Spyridon, Gavana Elpida, Papageorgiou Vasileios, Kotsa Kalliopi,

(4) Corrigendum to "Vitamin D-Binding Protein Clearance Ratio Is Significantly Associated with Glycemic Status and Diabetes Complications in a Predominantly Vitamin D-Deficient Population".[TOP]

Pubmed ID :30426020
Publication Date : //
[This corrects the article DOI: 10.1155/2018/6239158.].

Authors : Abdella Nabila A, Mojiminiyi Olusegun A,

(5) Circulating 25-hydroxyvitamin D, vitamin D binding protein and risk of advanced and lethal prostate cancer.[TOP]

Pubmed ID :30411792
Publication Date : //
We previously found that higher total 25-hydroxyvitamin D [25(OH)D] levels were associated with lower risk of lethal prostate cancer. However, the relationships of bioavailable 25(OH)D and vitamin D binding protein (VDBP) with risk of advanced and lethal prostate cancer are unclear. In a prospective case-control study of 156 pairs of advanced prostate cancer cases and controls, we directly measured prediagnostic circulating 25(OH)D and VDBP and calculated bioavailable 25(OH)D using a validated formula. We examined the association of bioavailable 25(OH)D and VDBP levels with risk of advanced and lethal prostate cancer and whether total 25(OH)D levels interacted with VDBP levels to affect the risk. Conditional logistic models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Compared to total 25(OH)D (p = 0.02), bioavailable 25(OH)D levels were not more strongly associated with risk of advanced prostate cancer (p = 0.14). Although VDBP levels were not associated with risk of advanced prostate cancer (p = 0.16), we observed an interaction between total 25(OH)D levels and VDBP levels in relation to risk of advanced prostate cancer (p = 0.03). Compared to those with total 25(OH)D levels below the median and VDBP levels above the median (at highest risk), men with both levels above the median had a multivariable-adjusted OR of 0.31 (95% CI, 0.15-0.65) for advanced prostate cancer. We observed similar results when we restricted the analyses to 116 lethal prostate cancer cases and their controls. Our data suggest that VDBP levels may modify the association between total 25(OH)D levels and risk of advanced and lethal prostate cancer.

Authors : Yuan Chen, Shui Irene M, Wilson Kathryn M, Stampfer Meir J, Mucci Lorelei A, Giovannucci Edward L,

(6) Serum Vitamin D Binding Protein Level Associated with Metabolic Cardiovascular Risk Factors in Women with the Polycystic Ovary Syndrome.[TOP]

Pubmed ID :30408832
Publication Date : //
The objective of the study was to measure the levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) and assess their relationships with cardiovascular risk factors in women with the polycystic ovary syndrome (PCOS). A group of 267 women, aged 20-35 years (24.7 ± 4.9): 167 with PCOS and 100 healthy women were divided according to body mass index. Biochemical and hormonal parameters were measured. Free and bioavailable 25(OH)D were calculated using the mathematical equations. The percentage of body fat and visceral fat deposit were assessed by DXA. In the normal weight control group total, free, bioavailable 25(OH)D (p<0.001 for all) were significantly higher than in its overweight/obese counterpart, while VDBP levels were comparable. In PCOS women total 25(OH)D (p<0.001), and VDBP (p -0.006) were lower in the overweight/obese subgroups than in the normal weight ones. In both groups serum VDBP levels correlated negatively with serum insulin and positively with sex hormone binding globulin. In PCOS group, in contrast to control group, VDPB was negatively correlated with abdominal fat deposit, BMI, fasting glucose and positively with HDL. Despite lower total 25(OH)D in obese PCOS women, all women with PCOS (lean and obese) had comparable free and bioavailable 25(OH)D, which might be a result of concomitantly lowered serum VDBP levels in obese PCOS women. VDBP might play important role in the regulation of availability of active fractions of 25(OH)D in PCOS women. VDBP seems to be associated with cardiovascular risk factors such as BMI, waist circumference, visceral fat, and fasting serum insulin in women with PCOS.

Authors : Kuliczkowska-Plaksej Justyna, Pasquali Renato, Milewicz Andrzej, Lwow Felicja, Jedrzejuk Diana, Bolanowski Marek,

(7) Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes.[TOP]

Pubmed ID :30405883
Publication Date : //
Mortality rate is increased in type 2 diabetes (T2D). Low vitamin D levels are associated with increased mortality risk in T2D. In the general population, genetic variants affecting vitamin D metabolism ( rs12785878, rs10741657, rs4588) have been associated with serum vitamin D. We studied the association of these variants with serum vitamin D in 2163 patients with T2D from the "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes". Measurements of serum vitamin D were centralised. Genotypes were obtained by Eco™ Real-Time PCR. Data were adjusted for gender, age, BMI, HbA1c, T2D therapy and sampling season. DHCR7 rs12785878 ( = 1 x 10-4) and rs4588 ( = 1 x 10-6) but not rs10741657 ( = 0.31) were significantly associated with vitamin D levels. One unit of a weighted genotype risk score (GRS) was strongly associated with vitamin D levels ( = 1.1 x 10-11) and insufficiency (<30 ng/ml) (OR, 95%CI = 1.28, 1.16-1.41, = 1.1 x 10-7). In conclusion, DHCR7 rs12785878 and rs4588, but not CYP2R1 rs10741657, are significantly associated with vitamin D levels. When the 3 variants were considered together as GRS, a strong association with vitamin D levels and vitamin D insufficiency was observed, thus providing robust evidence that genes involved in vitamin D metabolism modulate serum vitamin D in T2D.

Authors : Bertoccini Laura, Bailetti Diego, , Buzzetti Raffaella, Cavallo Maria Gisella, Copetti Massimiliano, Cossu Efisio, D'Angelo Paola, De Cosmo Salvatore, Di Mauro Lazzaro, Leonetti Frida, Morano Susanna, Morviducci Lelio, Napoli Nicola, Prudente Sabrina, Pugliese Giuseppe, Trischitta Vincenzo, Baroni Marco Giorgio,

(8) Proteomic landscape of seminal plasma associated with dairy bull fertility.[TOP]

Pubmed ID :30397208
Publication Date : //
Male fertility is the ability of sperm to fertilize the egg and sustain embryo development. Several factors determine the fertilizing capacity of mammalian sperm, including those intrinsic to sperm and components of the seminal plasma. The present study analyzed the seminal fluid proteome of Bos taurus and potential associations between proteins and fertility scores. Mass spectrometry coupled with nano HPLC allowed the identification of 1,159 proteins in the dairy bull seminal plasma. There were 50 and 29 seminal proteins more abundant in high (HF) low fertility (LF) bulls, respectively. Based on multivariate analysis, C-type natriuretic peptide, TIMP-2, BSP5 and sulfhydryl oxidase indicated relationship with HF bulls. Clusterin, tissue factor pathway inhibitor 2, galectin-3-binding protein and 5'-nucleotidase were associated with LF bulls. Abundance of NAD(P)(+)-arginine ADP-ribosyltransferase, prosaposin and transmembrane protein 2 proteins had the highest positive correlations with fertility ranking. Quantities of vitamin D-binding protein, nucleotide exchange factor SIL1 and galectin-3-binding protein showed the highest negative correlations with fertility ranking. A fertility ranking score was calculated and the relationship with these proteins was significant (Spearman's rho = 0.94). The present findings represent a major and novel contribution to the study of bovine seminal proteins. Indicators of fertility can be used to improve reproductive biotechnologies.

Authors : Viana A G A, Martins A M A, Pontes A H, Fontes W, Castro M S, Ricart C A O, Sousa M V, Kaya A, Topper E, Memili E, Moura A A,

(9) A reduced protein diet modulates enzymes of vitamin D and cholesterol metabolism in young ruminants.[TOP]

Pubmed ID :30394334
Publication Date : //
Besides other adverse effects, a low protein diet has been shown to modulate cholesterol and vitamin D metabolism in monogastric species like rats and humans. As ruminants can increase the efficiency of the rumino-hepatic circulation of urea, it is assumed that goats should be able to compensate for a low dietary protein intake better. After a dietary protein restriction (9% vs. 20%) for six weeks, plasma concentrations of urea, albumin, 1,25-dihydroxyvitamin D and calcium were decreased, while plasma 25-hydroxyvitamin D (25-OHD), and total cholesterol were significantly increased in young goats. Because this was not accompanied by any decrease in expression of CYP24A1 mRNA, we investigated mRNA expression of additional enzymes with known 24- and/or 25-hydroxylase activities (CYP2R1, CYP2J2, CYP3 A24, CYP27A1), receptors involved in their regulation (VDR, PXR, RXRα) and vitamin D binding protein (VDBP). CYP2R1expression was stimulated with the low dietary protein intake, negatively correlated with plasma urea and positively associated with serum 25-OHD. The greater plasma concentrations of total cholesterol could be explained with the reduction of CYP2J2 and CYP27A1 expression. None of the receptors investigated were affected by the dietary protein restriction but mRNA expression of VDBP was slightly reduced. Taken together our results show that dietary protein restriction has an impact on vitamin D and cholesterol metabolism in ruminants, too. Therefore, further investigations are needed before dietary interventions aiming at diminishing nitrogen excretion can be implemented.

Authors : Wilkens Mirja R, Firmenich Caroline S, Schnepel Nadine, Muscher-Banse Alexandra S,

(10) Vitamin D binding protein: a new biomarker of disease severity in lymphangioleiomyomatosis.[TOP]

Pubmed ID :30385604
Publication Date : //

Authors : Liu Heng-Jia, Henske Elizabeth P,