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Granulocyte_Macrophage Colony Stimulating Factor (GM_CSF), Clone CC305, Mab anti_Bovine; ELISA_WB

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[#YSRTMCA1828] Granulocyte_Macrophage Colony Stimulating Factor (GM_CSF), Clone CC305, Mab anti_Bovine; ELISA_WB


YSRTMCA1828 | Granulocyte_Macrophage Colony Stimulating Factor (GM_CSF), Clone CC305, Mab anti_Bovine; ELISA_WB, 0.5 mg.
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(1) Pulmonary Alveolar Proteinosis in Hereditary and Autoimmune Forms With 2 Cases.[TOP]

Pubmed ID :30113436
Publication Date : //
Pulmonary alveolar proteinosis (PAP) is a respiratory pathology characterized by the accumulation and increase of surfactant-derived material in the lungs. In clinical practice, PAP may present as the primary form, which includes autoimmune and hereditary PAP, or as the secondary form. Diffuse alveolar radiopacities on chest x-ray and the crazy-paving pattern on high-resolution computed tomography are important, although not specific findings for PAP. Bronchoalveolar lavage biopsy is a diagnostic method, and whole-lung lavage remains the criterion standard for the treatment of PAP. Evidence is required regarding treatment with exogenous anti-granulocyte/macrophage colony-stimulating factor.Here, we present a 13-year-old male patient with hereditary PAP and a 15-year-old female patient with autoimmune PAP who presented with complaints of easy fatigability and weakness to emphasize the importance of keeping in mind PAP as a differential diagnosis in patients with respiratory failure findings.

Authors : Sirin Kose Seda, Asilsoy Suna, Uzuner Nevin, Karaman Ozkan, Ozer Erdener, Anal Ozden,

(2) C3a is required for ILC2 function in allergic airway inflammation.[TOP]

Pubmed ID :30104625
Publication Date : //
Aberrant type 2 responses underlie the pathologies in allergic diseases like asthma, yet, our understanding of the mechanisms that drive them remains limited. Recent evidence suggests that dysregulated innate immune factors can perpetuate asthma pathogenesis. In susceptible individuals, allergen exposure triggers the activation of complement, a major arm of innate immunity, leading to the aberrant generation of the C3a anaphylatoxin. C3 and C3a have been shown to be important for the development of Th2 responses, yet remarkably, the mechanisms by which C3a regulates type 2 immunity are relatively unknown. We demonstrate a central role for C3a in driving type 2 innate lymphoid cells (ILC2)-mediated inflammation in response to allergen and IL-33. Our data suggests that ILC2 recruitment is C3a-dependent. Further, we show that ILC2s directly respond to C3a, promoting type 2 responses by specifically: (1) inducing IL-13 and granulocyte-macrophage colony-stimulating factor, whereas inhibiting IL-10 production from ILC2; and (2) enhancing their antigen-presenting capability during ILC-T-cell cross-talk. In summary, we identify a novel mechanism by which C3a can mediate aberrant type 2 responses to aeroallergen exposure, which involves a yet unrecognized cross-talk between two major innate immune components-complement and group 2 innate lymphoid cells.

Authors : Gour Naina, Smole Ursula, Yong Hwan-Mee, Lewkowich Ian P, Yao Nu, Singh Anju, Gabrielson Edward, Wills-Karp Marsha, Lajoie Stephane,

(3) Granulocyte-macrophage colony-stimulating factor (GM-CSF) improves mouse peripheral nerve regeneration following sciatic nerve crush.[TOP]

Pubmed ID :30099786
Publication Date : //
Peripheral nerve injuries severely impair patients' quality of life since full recovery is seldom achieved. Upon axonal disruption, the distal nerve stump undergoes fragmentation, and myelin breaks down; the subsequent regeneration progression is dependent on cell debris removal. In addition to tissue clearance, macrophages release angiogenic and neurotrophic factors that contribute to axon growth. Based on the importance of macrophages for nerve regeneration, especially during the initial response to injury, we treated mice with granulocyte-macrophage colony-stimulating factor (GM-CSF) at various intervals after sciatic nerve crushing. Sciatic nerves were histologically analyzed at different time intervals after injury for the presence of macrophages and indicators of regeneration. Functional recovery was followed by an automated walking track test. We found that GM-CSF potentiated early axon growth, as indicated by the enhanced expression of growth-associated protein at 7 days postinjury. Inducible nitric oxide synthase expression increased at the beginning and at the end of the regenerative process, suggesting that nitric oxide is involved in axon growth and pruning. As expected, GM-CSF treatment stimulated macrophage infiltration, which increased at 7 and 14 days; however, it did not improve myelin clearance. Instead, GM-CSF stimulated early brain-derived neurotrophic factor (BDNF) production, which peaked at 7 days. Locomotor recovery pattern was not improved by GM-CSF treatment. The present results suggest that GM-CSF may have beneficial effects on early axonal regeneration. This article is protected by copyright. All rights reserved.

Authors : Bombeiro André Luis, Pereira Bruna Toledo Nunes, de Oliveira Alexandre Leite Rodrigues,

(4) Characteristics of Sinus Fungus Ball: A Unique Form of Rhinosinusitis.[TOP]

Pubmed ID :30090023
Publication Date : //
The purpose of this study was to investigate the characteristics of this unique form of rhinosinusitis.

Authors : Jiang Rong-San, Huang Wan-Chun, Liang Kai-Li,

(5) Blastocystis sp., parasite associated with gastrointestinal disorders: An overview of its pathogenesis, immune modulation and therapeutic strategies.[TOP]

Pubmed ID :30084327
Publication Date : //
Blastocystis sp. is a unicellular parasitic microorganism commonly found in the gastrointestinal tracts of humans and animals. It causes symptomatic or asymptomatic infection and its route of transmission is via fecal-oral. High prevalence of Blastocystis infection in developing countries is usually due to poor hygiene practices, exposure to animals infected with the parasite and intake of contaminated water or food. Blastocystis infected individuals often suffer from diarrhea, abdominal pain, nausea, and stomach bloating. Even though pathogenecity of Blastocystis is unclear, it is commonly associated with irritable bowel syndrome. In this review we have analysed the evidences that shows the association between this microorganism and gastrointestinal disorders. There have been a number of studies which showed that the pathogenicity of Blastocystis is related to its different STs. The pathogenicity is speculated to be due to cysteine proteases formation which stimulates mucosal cells to release interleukin-8 which has been associated with extreme dehydration and gut inflammation. In vitro studies on human colonic epithelial cells revealed that incubation of Blastocystis modulated the host immune response by stimulating the formation of pro-inflammatory cytokines and granulocyte macrophage colony-stimulating factor. Metronidazole is found to be the first-line drug of choice. Other treatment option is the combination therapy with trimethoprim/sulfamethoxazole.

Authors : Kumarasamy Vinoth, Anbazhagan Deepa, Subramaniyan Vetriselvan, Vellasamy Shalini,

(6) Disseminated Cryptococcus gattii infection preceding onset of pulmonary alveolar proteinosis.[TOP]

Pubmed ID :30083345
Publication Date : //
A 50-year-old immunocompetent man presented with intracranial space-occupying lesions and a right lung mass. This was found to be disseminated Cryptococcus gattii infection. Following 15 months of anti-fungal therapy, imaging showed reduction in the size of the pulmonary cryptococcoma and new multi-lobar ground-glass opacities interspersed with a crazy-paving pattern. Surgical lung biopsy was performed after bronchoscopic evaluation was non-yielding. Histology showed intra-alveolar accumulation of foamy macrophages and airspaces containing periodic acid Schiff-positive amorphous eosinophilic material with strong immune positivity for surfactant A, consistent with a diagnosis of pulmonary alveolar proteinosis (PAP). The majority of adult-onset PAP is due to the presence of anti-granulocyte macrophage colony-stimulating factor antibodies. Opportunistic fungal and mycobacterial infections are known to occur in these patients due to alveolar macrophage and neutrophilic dysfunction. The onset of PAP may occur concurrently with, or be temporally distinct from, opportunistic infections. For patients with respiratory failure, whole lung lavage is a therapeutic strategy.

Authors : Quah Jessica, Low Teck Boon, Fong Raymond,

(7) Combination of Suicide and Cytokine Gene Therapies as Surgery Adjuvant for Canine Mammary Carcinoma.[TOP]

Pubmed ID :30081470
Publication Date : //
The incidence of canine mammary carcinoma varies with age, breed, and spay status, being among the main tumors appearing in intact female dogs. Thirty-six canine mammary carcinoma patients received injections of canine interferon-β (cIFN-β) and HSV-thymidine kinase/ganciclovir (HSV-tk/GCV) carrying lipoplexes, into the tumor bed, immediately after surgery. Next, they started periodic subcutaneous injections of lipoplexes carrying a human granulocyte-macrophage colony stimulating factor and interleukin-2 mixed with allogeneic mammary carcinoma extracts. This combined strategy was safe and well tolerated. In addition, only two out of 26 patients treated with complete surgery developed a local relapse, and 0 out of 29 stage II and III patients displayed distant metastases, suggesting both local and systemic antitumor activities. The most encouraging result was the long survival times: 22 > 1 year (where 13 > 2 and 4 > 3 years), while maintaining a good quality of life. The preliminary results in five patients presenting with local disease, an additional HSV-tk/GCV plus cIFN-β gene treatment induced local antitumor activity, evidenced by four objective responses (one complete, three partial) and one stable disease. This successful outcome supports further studies to validate this approach not only for canine veterinary patients, but also for translation to human patients.

Authors : Finocchiaro Liliana M E, Spector Agustina I M, Agnetti Lucrecia, Arbe M Florencia, Glikin Gerardo C,

(8) IL-5 in follicular fluid as a negative predictor of the intracytoplasmic sperm injection outcome.[TOP]

Pubmed ID :30072087
Publication Date : //
To determine the prognostic value of intrafollicular concentrations of some cytokines from women undergoing ovarian stimulation in the outcome of intracytoplasmic sperm injection/embryo transfer (ICSI/ET) cycles.

Authors : Alhilali Miaad Jabbar Sahib, Parham Abbas, Attaranzadeh Armin, Amirian Malihe, Azizzadeh Mohammad,

(9) Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis.[TOP]

Pubmed ID :30064991
Publication Date : //
Critically ill patients with impaired neutrophil phagocytosis have significantly increased risk of nosocomial infection. Granulocyte-macrophage colony-stimulating factor (GM-CSF) improves phagocytosis by neutrophils ex vivo. This study tested the hypothesis that GM-CSF improves neutrophil phagocytosis in critically ill patients in whom phagocytosis is known to be impaired.

Authors : Pinder Emma M, Rostron Anthony J, Hellyer Thomas P, Ruchaud-Sparagano Marie-Helene, Scott Jonathan, Macfarlane James G, Wiscombe Sarah, Widdrington John D, Roy Alistair I, Linnett Vanessa C, Baudouin Simon V, Wright Stephen E, Chadwick Thomas, Fouweather Tony, Juss Jatinder K, Chilvers Edwin R, Bowett Susan A, Parker Jennie, McAuley Daniel F, Conway Morris Andrew, Simpson A John,

(10) Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions.[TOP]

Pubmed ID :30062729
Publication Date : //
We examined the mechanisms underlying the positive effect of preconditioning contractions (PCs) on the recovery of muscle force after damaging eccentric contractions (ECCs). The mechanisms underlying the immediate force decrease after damaging ECCs differ from those causing depressed force with a few days' delay, where reactive oxygen species (ROS) produced by invading immune cells play an important causative role. PCs counteracted the delayed onset force depression and this could be explained by prevention of immune cell invasion, which resulted in decreased myeloperoxidase-mediated ROS production, hence avoiding cell membrane disruption, calpain activation and degenerative changes in myosin and actin molecules.

Authors : Yamada Ryotaro, Himori Koichi, Tatebayashi Daisuke, Ashida Yuki, Ikezaki Kazumi, Miyata Hirohumi, Kanzaki Keita, Wada Masanobu, Westerblad Håkan, Yamada Takashi,