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ELISA Kit for Thy1 Cell Surface Antigen (Thy1)

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[#E91404Ra] ELISA Kit for Thy1 Cell Surface Antigen (Thy1)


E91404Ra | ELISA Kit for Thy1 Cell Surface Antigen (Thy1), 96T/Kit
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(1) Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells.[TOP]

Pubmed ID :15851488
Publication Date : //
Notch signaling regulates multiple cell fate decisions by hematopoietic precursors. To address whether different amounts of Notch ligand influence lineage choices, we cultured murine bone marrow lin(-)Sca-1(+)c-kit+ cells with increasing densities of immobilized Delta1(ext-IgG) consisting of the extracellular domain of Delta1 fused to the Fc domain of human IgG1. We found that relatively lower densities of Delta1(ext-IgG) enhanced the generation of Sca-1(+)c-kit+ cells, Thy1(+)CD25+ early T cell precursors, and B220(+)CD43(-/lo) cells that, when cocultured with OP9 stroma cells, differentiated into CD19+ early B cell precursors. Higher densities of Delta1(ext-IgG) also enhanced the generation of Sca-1(+)c-kit+ precursor cells and promoted the development of Thy1(+)CD25+ cells, but inhibited the development of B220(+)CD43(-/lo) cells. Analyses of further isolated precursor populations suggested that the enhanced generation of T and B cell precursors resulted from the effects on multipotent rather than lymphoid-committed precursors. The results demonstrate the density-dependent effects of Delta1 on fate decisions of hematopoietic precursors at multiple maturational stages and substantiate the previously unrecognized ability of Delta1 to enhance the development of both early B and T precursor cells.

Authors : Dallas Mari H, Varnum-Finney Barbara, Delaney Colleen, Kato Keizo, Bernstein Irwin D,