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ELISA Kit for Early Prostate Cancer Antigen 2 (EPCA2)

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[#E84215Hu] ELISA Kit for Early Prostate Cancer Antigen 2 (EPCA2)


E84215Hu | ELISA Kit for Early Prostate Cancer Antigen 2 (EPCA2) , 96T/Kit
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(1) Burden of familial heterozygous hypercholesterolemia in Uzbekistan: Time is muscle.[TOP]

Pubmed ID :30270094
Publication Date : //
We aimed to assess the disease burden and to study the molecular genetic characteristics of heterozygous familial hypercholesterolemia (HeFH) patients within the Uzbek population to develop a program of early disease detection and effective treatment measures.

Authors : Shek Aleksandr, Alieva Rano, Kurbanov Ravshanbek, Hoshimov Shavkat, Nizamov Ulugbek, Abdullaeva Guzal, Nagay Aleksandr,

(2) Filarial infection during pregnancy has profound consequences on immune response and disease outcome in children: A birth cohort study.[TOP]

Pubmed ID :30252839
Publication Date : //
Current Global Program to Eliminate Lymphatic Filariasis (GPELF) that prohibits pregnant mothers and children below two years of age from coverage targeted interruption of transmission after 5-6 rounds of annual mass drug administration (MDA). However, after more than 10 rounds of MDA in India the target has not been achieved, which poses challenge to the researchers and policy makers. Several studies have shown that in utero exposure to maternal filarial infections plays certain role in determining the susceptibility and disease outcome in children. But the mechanism of which has not been studied extensively. Therefore the present study was undertaken to understand the mechanism of immune modulation in children born to filarial infected mother in a MDA ongoing area.

Authors : Bal Madhusmita, Ranjit Manoranjan, Satapathy Ashok K, Khuntia Hemant K, Pati Sanghamitra,

(3) Serum caveolin-1 levels in patients with preeclampsia.[TOP]

Pubmed ID :30249137
Publication Date : //
The expressions of caveolin-1 have only been examined in the placental tissue of patients with preeclampsia and were reported to be low. Therefore, we decided to investigate the maternal serum levels of caveolin-1 in patients with preeclampsia.

Authors : Cift Tayfur, Begum Aydogan Mathyk, Aslan Cetin Berna, Erenel Hakan, Tuten Abdullah, Bulut Berk, Yilmaz Nevin, Ekmekci Hakan, Gezer Altay,

(4) Diagnostic value of platelet-derived microparticles in pulmonary thromboembolism: A population-based study.[TOP]

Pubmed ID :30233670
Publication Date : //
An early and accurate diagnosis of pulmonary thromboembolism (PTE) remains challenging. The present study aimed to evaluate the diagnostic value of platelet-derived microparticles in PTE based on a population study. A total of 102 patients with PTE, 102 healthy controls and 40 patients suspected with PTE were enrolled in this study. The platelet count, mean platelet volume and platelet distribution width were assessed using an automated hematology analyzer, P-selectin was assessed using an ELISA kit and PMPs were explored using flow cytometry using Megamix beads. Receiver operating characteristic curves were established to evaluate the diagnostic values of PMPs, D-dimer, PMPs combined with D-dimer, and multiple parameters (including PMPs, platelet distribution width, P-selectin and D-dimer in PTE). The PMP levels were significantly higher in the patients with PTE (609.10/µl) compared with those in the healthy controls (230.60/µl) and patients with suspicious PTE (166.70/µl; P<0.01). The accuracy (72.06%) of PMPs in the diagnosis of PTE was similar to those of D-dimer (P>0.05). The combination of D-dimer and PMPs significantly increased the sensitivity (86.27%) of D-dimer and the specificity of PMP for the diagnosis of PTE (P<0.01). The combination of PMPs, platelet distribution width, P-selectin and D-dimer exhibited high sensitivity (88.24%), specificity (91.18%) and accuracy (89.71%) in the diagnosis of PTE. These findings suggest that elevated PMP levels are an effective predictor of PTE. The combination of PMPs, platelet distribution width, P-selectin and D-dimer may be used in the diagnosis of PTE with high sensitivity and specificity.

Authors : Wang Minglian, Fu Yingyun, Xu Lan, Xiao Lu, Yue Yongjian, Liu Shengguo, Huang Qijun, Li Shulin, Li Yazhen,

(5) Novel protein chip for the detection of antibodies against infectious bronchitis virus.[TOP]

Pubmed ID :30223836
Publication Date : //
Infectious bronchitis (IB) caused by the IB virus (IBV) can cause acute damage to chickens around the world. Therefore, rapid diagnosis and immune status determination are critical for controlling IBV outbreaks. Enzyme-linked immunosorbent assays (ELISAs) have been widely used in the detection of IBV antibodies in the early infection and continuous infection of IB because they are more sensitive and quicker than other diagnostic methods.

Authors : Yan Liping, Hu Jianhua, Lei Jing, Shi Zhiyu, Xiao Qian, Bi Zhenwei, Yao Lu, Li Yuan, Chen Yuqing, Fang An, Li Hui, Song Suquan, Liao Min, Zhou Jiyong,

(6) Strontium ion attenuates lipopolysaccharide-stimulated proinflammatory cytokine expression and lipopolysaccharide-inhibited early osteogenic differentiation of human periodontal ligament cells.[TOP]

Pubmed ID :30221352
Publication Date : //
Periodontitis is a chronic inflammatory disease characterized by the destruction of the periodontium. The strontium ion (Sr ) can prevent the bone loss associated with periodontitis and promote the regeneration of the bone. The mechanisms by which the Sr works remain poorly understood. We aim to investigate the effects of the Sr ion on cell proliferation, inflammatory regulation and osteogenic differentiation of human periodontal ligament cells (hPDLCs) in pathological conditions.

Authors : Wei Lingfei, Jiang Yuxi, Zhou Wenjuan, Liu Shutai, Liu Yuelian, Rausch-Fan Xiaohui, Liu Zhonghao,

(7) Neutralizing antibodies against Simbu serogroup viruses in cattle and sheep, Nigeria, 2012-2014.[TOP]

Pubmed ID :30200958
Publication Date : //
Simbu serogroup viruses of the Orthobunyavirus genus (Family Peribunyaviridae) include teratogenic pathogens that cause severe economic losses, abortions, stillbirths and congenital abnormalities in ruminants worldwide. Although they were initially isolated from ruminants and Culicoides biting midges about five decades ago in Nigeria, there is no current information on their prevalence and geographical distribution despite reports of abortions and congenital malformations in the country's ruminant population. Here, apparently healthy cattle and sheep obtained from eight states in the three major vegetation zones of Nigeria were screened for the presence of specific neutralizing antibodies against Schmallenberg virus (SBV), Simbu virus (SIMV) and Shamonda virus (SHAV).

Authors : Oluwayelu Daniel, Wernike Kerstin, Adebiyi Adebowale, Cadmus Simeon, Beer Martin,

(8) Salivary opiorphin levels in anorexia nervosa: a case control study.[TOP]

Pubmed ID :30179071
Publication Date : //
Opiorphin is a physiological inhibitor of peptidases inactivating endogenous opioids displaying strong analgesic properties without undesirable side effects, antidepressant properties and hormonal dependency. It might therefore play an important role in patients with painful diseases related to neuro-hormonal dysregulation of the nervous system, affecting saliva secretion and composition such as anorexia (AN). The main objective aim of this study was to compare the level of opiorphin in saliva of patients with AN to matched subjects free of eating disorders.

Authors : Paszynska Elzbieta, Dmitrzak-Weglarz Monika, Roszak Magdalena, Boucher Yves, Dutkiewicz Agata, Tyszkiewicz-Nwafor Marta, Gawriolek Maria, Otulakowska-Skrzynska Justyna, Rzatowski Szymon, Słopień Agnieszka,

(9) Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß-Treated MS Patients.[TOP]

Pubmed ID :30178232
Publication Date : //
Multiple sclerosis (MS) is a central nervous system autoimmune disease characterized by demyelination. Autoreactive T cells mainly interferon gamma (IFN-γ) producing T helper cells (Th1) have an important role in MS pathogenesis. Silymarin is a unique blend produced from milk thistle (Silybum marianum) plant which its imunomodulatory role has been indicated in studies. In the present study, the effects of silymarin on isolated Th1 cells were investigated in newly diagnosed MS patients and those who received betaferon. PBMCs were separated from newly diagnosed and IFN-β-treated MS patients. The Th1 cell isolation from PBMCs was performed using a human Th1 cell isolation kit. Th1 cells were cultured in the presence of silymarin (50, 100, and 150 μM for 48, 72, and 120 h). Th1 cell proliferation and CD69 expression were assessed by flow cytometry. Also, IFN-γ production and T-bet gene expression were measured by ELISA and real-time PCR respectively. In vitro cultured Th1 cells showed that silymarin suppresses Th1 cell proliferation dose and time dependently in newly diagnosed and IFN-β-treated MS patients in comparison to DMSO control. Also, CD69 expression as an early activation marker was changed after Th1 cell treatment with different doses of silymarin at different times. T-bet gene expression was significantly decreased in Th1 cells isolated from newly diagnosed and IFN-β-treated RRMS patients after treatment with silymarin compared to DMSO control. Additionally, IFN-γ production by Th1 cells was decreased after treatment silymarin in newly diagnosed patients; however, in IFN-β treated after 48-h treatment with silymarin, IFN-γ concentration was decreased at concentrations of 100 and 150 μM, and after 120 h, a significant increase was observed in the IFN-γ level at a concentration of 100 μM in comparison with DMSO. Our findings here clearly show that silymarin is an effective regulator for Th1 response in vitro condition. It not only suppresses Th1 proliferating activity but also inhibits T-bet gene expression and IFN-γ production by these cells.

Authors : Navabi Fereshteh, Shaygannejad Vahid, Abbasirad Faezeh, Vaez Elaheh, Hosseininasab Fahimeh, Kazemi Mohammad, Mirmosayyeb Omid, Alsahebfosoul Fereshteh, Esmaeil Nafiseh,

(10) G-CSF associates with neurogenesis and predicts prognosis and sensitivity to chemotherapy in pancreatic ductal adenocarcinoma.[TOP]

Pubmed ID :30147373
Publication Date : //
Recent studies demonstrated that granulocyte colony-stimulating factor (G-CSF), regularly used for the prevention of neutropenia, is engaged in cancer progression. However, the role of G-CSF in pancreatic ductal adenocarcinoma (PDAC) is not clear. The aim of the present study was to investigate the expression and prognostic value of G-CSF in patients with PDAC.

Authors : Zhang Lingfu, Tao Lianyuan, Guo Limei, Zhan Jun, Yuan Chunhui, Ma Zhaolai, Jiang Bin, Xiu Dianrong,